| PAVELEK, Zbyšek, Oldřich VYŠATA, Lukáš SOBÍŠEK, Blanka KLÍMOVA, Ctirad ANDRÝS, Doris VOKURKOVÁ, Radka MAZUROVÁ, Pavel ŠTOURAČ and Martin VALIŠ. Lymphocyte populations and their change during five-year glatiramer acetate treatment. Neurologia i Neurochirurgia Polska. Poznan: Termedia Publishing House LTD, 2018, vol. 52, No 5, p. 587-592. ISSN 0028-3843. Available from: https://dx.doi.org/10.1016/j.pjnns.2018.08.001. |
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@article{1455737,
author = {Pavelek, Zbyšek and Vyšata, Oldřich and Sobíšek, Lukáš and Klímova, Blanka and Andrýs, Ctirad and Vokurková, Doris and Mazurová, Radka and Štourač, Pavel and Vališ, Martin},
article_location = {Poznan},
article_number = {5},
doi = {http://dx.doi.org/10.1016/j.pjnns.2018.08.001},
keywords = {Multiple sclerosis; Lymphocytes; Glatiramer acetate; Parameters; Treatment},
language = {eng},
issn = {0028-3843},
journal = {Neurologia i Neurochirurgia Polska},
title = {Lymphocyte populations and their change during five-year glatiramer acetate treatment},
volume = {52},
year = {2018}
}
TY - JOUR
ID - 1455737
AU - Pavelek, Zbyšek - Vyšata, Oldřich - Sobíšek, Lukáš - Klímova, Blanka - Andrýs, Ctirad - Vokurková, Doris - Mazurová, Radka - Štourač, Pavel - Vališ, Martin
PY - 2018
TI - Lymphocyte populations and their change during five-year glatiramer acetate treatment
JF - Neurologia i Neurochirurgia Polska
VL - 52
IS - 5
SP - 587-592
EP - 587-592
PB - Termedia Publishing House LTD
SN - 00283843
KW - Multiple sclerosis
KW - Lymphocytes
KW - Glatiramer acetate
KW - Parameters
KW - Treatment
N2 - Background: The goal of this study was to determine the characteristics that are affected in patients treated with glatiramer acetate (GA). Methods: A total of 113 patients were included in this study. Patients were treated with glatiramer acetate (subcutaneous injection, 20 mg, each day). Peripheral blood samples were obtained just prior to treatment as well as 5 years after GA treatment. All the calculations were performed with the statistical system R (r-project.org). Results: After 5 years of treatment, a significant decrease was found in the absolute and relative CD3+/CD69+ counts, the absolute and relative CD69 counts, the relative CD8+/CD38+ count and the relative CD38 count. A significant increase was found in the absolute and relative CD5+/CD45RA+ counts and the absolute CD5+/CD45RO+ count after 5 years of treatment. Conclusion: This study presents some parameters that were affected by long-term GA treatment. (C) 2018 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.
ER -
PAVELEK, Zbyšek, Oldřich VYŠATA, Lukáš SOBÍŠEK, Blanka KLÍMOVA, Ctirad ANDRÝS, Doris VOKURKOVÁ, Radka MAZUROVÁ, Pavel ŠTOURAČ and Martin VALIŠ. Lymphocyte populations and their change during five-year glatiramer acetate treatment. \textit{Neurologia i Neurochirurgia Polska}. Poznan: Termedia Publishing House LTD, 2018, vol.~52, No~5, p.~587-592. ISSN~0028-3843. Available from: https://dx.doi.org/10.1016/j.pjnns.2018.08.001.
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