PAVELEK, Zbyšek, Oldřich VYŠATA, Lukáš SOBÍŠEK, Blanka KLÍMOVA, Ctirad ANDRÝS, Doris VOKURKOVÁ, Radka MAZUROVÁ, Pavel ŠTOURAČ and Martin VALIŠ. Lymphocyte populations and their change during five-year glatiramer acetate treatment. Neurologia i Neurochirurgia Polska. Poznan: Termedia Publishing House LTD, 2018, vol. 52, No 5, p. 587-592. ISSN 0028-3843. Available from: https://dx.doi.org/10.1016/j.pjnns.2018.08.001. |
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@article{1455737, author = {Pavelek, Zbyšek and Vyšata, Oldřich and Sobíšek, Lukáš and Klímova, Blanka and Andrýs, Ctirad and Vokurková, Doris and Mazurová, Radka and Štourač, Pavel and Vališ, Martin}, article_location = {Poznan}, article_number = {5}, doi = {http://dx.doi.org/10.1016/j.pjnns.2018.08.001}, keywords = {Multiple sclerosis; Lymphocytes; Glatiramer acetate; Parameters; Treatment}, language = {eng}, issn = {0028-3843}, journal = {Neurologia i Neurochirurgia Polska}, title = {Lymphocyte populations and their change during five-year glatiramer acetate treatment}, volume = {52}, year = {2018} }
TY - JOUR ID - 1455737 AU - Pavelek, Zbyšek - Vyšata, Oldřich - Sobíšek, Lukáš - Klímova, Blanka - Andrýs, Ctirad - Vokurková, Doris - Mazurová, Radka - Štourač, Pavel - Vališ, Martin PY - 2018 TI - Lymphocyte populations and their change during five-year glatiramer acetate treatment JF - Neurologia i Neurochirurgia Polska VL - 52 IS - 5 SP - 587-592 EP - 587-592 PB - Termedia Publishing House LTD SN - 00283843 KW - Multiple sclerosis KW - Lymphocytes KW - Glatiramer acetate KW - Parameters KW - Treatment N2 - Background: The goal of this study was to determine the characteristics that are affected in patients treated with glatiramer acetate (GA). Methods: A total of 113 patients were included in this study. Patients were treated with glatiramer acetate (subcutaneous injection, 20 mg, each day). Peripheral blood samples were obtained just prior to treatment as well as 5 years after GA treatment. All the calculations were performed with the statistical system R (r-project.org). Results: After 5 years of treatment, a significant decrease was found in the absolute and relative CD3+/CD69+ counts, the absolute and relative CD69 counts, the relative CD8+/CD38+ count and the relative CD38 count. A significant increase was found in the absolute and relative CD5+/CD45RA+ counts and the absolute CD5+/CD45RO+ count after 5 years of treatment. Conclusion: This study presents some parameters that were affected by long-term GA treatment. (C) 2018 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved. ER -
PAVELEK, Zbyšek, Oldřich VYŠATA, Lukáš SOBÍŠEK, Blanka KLÍMOVA, Ctirad ANDRÝS, Doris VOKURKOVÁ, Radka MAZUROVÁ, Pavel ŠTOURAČ and Martin VALIŠ. Lymphocyte populations and their change during five-year glatiramer acetate treatment. \textit{Neurologia i Neurochirurgia Polska}. Poznan: Termedia Publishing House LTD, 2018, vol.~52, No~5, p.~587-592. ISSN~0028-3843. Available from: https://dx.doi.org/10.1016/j.pjnns.2018.08.001.
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