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@article{1455936,
author = {Nechvátalová, Jana and Bartol, Sophinus J. W. and Chovancová, Zita and Boon, Louis and Vlková, Marcela and Zelm, Menno C. van},
article_location = {Bethesda},
article_number = {7},
doi = {http://dx.doi.org/10.4049/jimmunol.1800767},
keywords = {Surface IgD},
language = {eng},
issn = {0022-1767},
journal = {Journal of immunology},
title = {Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans},
volume = {201},
year = {2018}
}
TY - JOUR
ID - 1455936
AU - Nechvátalová, Jana - Bartol, Sophinus J. W. - Chovancová, Zita - Boon, Louis - Vlková, Marcela - Zelm, Menno C. van
PY - 2018
TI - Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans
JF - Journal of immunology
VL - 201
IS - 7
SP - 1928-1935
EP - 1928-1935
PB - American association of immunologists
SN - 00221767
KW - Surface IgD
N2 - Surface IgD is coexpressed with IgM on naive mature B cells. Still, the role of surface IgD remains enigmatic even 50 y after its initial discovery. In this study, we examined the in vivo role of surface IgD in human B cell homeostasis and Ab responses in four individuals with heterozygous nonsense mutations in IGHD. All IGHD heterozygous individuals had normal numbers of B cells and serum Igs and did not show signs of immunodeficiency or immune dysregulation. IgD(+) and IgD(-) naive mature B cells were present in equal numbers and showed similar immunophenotypes, except for decreased expression of CD79b in the IgD(-) subset. Furthermore, both IgD(+) and IgD(-) naive mature B cells had normal replication histories and similar capacities to differentiate into plasma cells upon in vitro stimulation, and Ig class-switched memory B cells showed similar levels of somatic hypermutations. Thus, human B cells lacking IgD expression develop normally and generate immunological memory in vivo, suggesting that surface IgD might function more restrictedly in regulating of B cell activation to specific antigenic structures.
ER -
NECHVÁTALOVÁ, Jana, Sophinus J. W. BARTOL, Zita CHOVANCOVÁ, Louis BOON, Marcela VLKOVÁ and Menno C. van ZELM. Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans. \textit{Journal of immunology}. Bethesda: American association of immunologists, vol.~201, No~7, p.~1928-1935. ISSN~0022-1767. doi:10.4049/jimmunol.1800767. 2018.
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