NECHVÁTALOVÁ, Jana, Sophinus J. W. BARTOL, Zita CHOVANCOVÁ, Louis BOON, Marcela VLKOVÁ and Menno C. van ZELM. Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans. Journal of immunology. Bethesda: American association of immunologists, 2018, vol. 201, No 7, p. 1928-1935. ISSN 0022-1767. doi:10.4049/jimmunol.1800767.
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Basic information
Original name Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans
Authors NECHVÁTALOVÁ, Jana (203 Czech Republic, belonging to the institution), Sophinus J. W. BARTOL (528 Netherlands), Zita CHOVANCOVÁ (203 Czech Republic, belonging to the institution), Louis BOON (528 Netherlands), Marcela VLKOVÁ (203 Czech Republic, belonging to the institution) and Menno C. van ZELM (528 Netherlands, guarantor).
Edition Journal of immunology, Bethesda, American association of immunologists, 2018, 0022-1767.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30102 Immunology
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 4.718
RIV identification code RIV/00216224:14110/18:00106940
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.4049/jimmunol.1800767
UT WoS 000444804300014
Keywords in English Surface IgD
Tags 14110114, rivok
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 9. 2. 2019 19:54.
Abstract
Surface IgD is coexpressed with IgM on naive mature B cells. Still, the role of surface IgD remains enigmatic even 50 y after its initial discovery. In this study, we examined the in vivo role of surface IgD in human B cell homeostasis and Ab responses in four individuals with heterozygous nonsense mutations in IGHD. All IGHD heterozygous individuals had normal numbers of B cells and serum Igs and did not show signs of immunodeficiency or immune dysregulation. IgD(+) and IgD(-) naive mature B cells were present in equal numbers and showed similar immunophenotypes, except for decreased expression of CD79b in the IgD(-) subset. Furthermore, both IgD(+) and IgD(-) naive mature B cells had normal replication histories and similar capacities to differentiate into plasma cells upon in vitro stimulation, and Ig class-switched memory B cells showed similar levels of somatic hypermutations. Thus, human B cells lacking IgD expression develop normally and generate immunological memory in vivo, suggesting that surface IgD might function more restrictedly in regulating of B cell activation to specific antigenic structures.
Links
NV15-28732A, research and development projectName: Vliv granulocytů a monocytů na vznik a rozvoj imunodeficitních chorob a dalších imunopatologických dějů
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