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@article{1455936, author = {Nechvátalová, Jana and Bartol, Sophinus J. W. and Chovancová, Zita and Boon, Louis and Vlková, Marcela and Zelm, Menno C. van}, article_location = {Bethesda}, article_number = {7}, doi = {http://dx.doi.org/10.4049/jimmunol.1800767}, keywords = {Surface IgD}, language = {eng}, issn = {0022-1767}, journal = {Journal of immunology}, title = {Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans}, volume = {201}, year = {2018} }
TY - JOUR ID - 1455936 AU - Nechvátalová, Jana - Bartol, Sophinus J. W. - Chovancová, Zita - Boon, Louis - Vlková, Marcela - Zelm, Menno C. van PY - 2018 TI - Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans JF - Journal of immunology VL - 201 IS - 7 SP - 1928-1935 EP - 1928-1935 PB - American association of immunologists SN - 00221767 KW - Surface IgD N2 - Surface IgD is coexpressed with IgM on naive mature B cells. Still, the role of surface IgD remains enigmatic even 50 y after its initial discovery. In this study, we examined the in vivo role of surface IgD in human B cell homeostasis and Ab responses in four individuals with heterozygous nonsense mutations in IGHD. All IGHD heterozygous individuals had normal numbers of B cells and serum Igs and did not show signs of immunodeficiency or immune dysregulation. IgD(+) and IgD(-) naive mature B cells were present in equal numbers and showed similar immunophenotypes, except for decreased expression of CD79b in the IgD(-) subset. Furthermore, both IgD(+) and IgD(-) naive mature B cells had normal replication histories and similar capacities to differentiate into plasma cells upon in vitro stimulation, and Ig class-switched memory B cells showed similar levels of somatic hypermutations. Thus, human B cells lacking IgD expression develop normally and generate immunological memory in vivo, suggesting that surface IgD might function more restrictedly in regulating of B cell activation to specific antigenic structures. ER -
NECHVÁTALOVÁ, Jana, Sophinus J. W. BARTOL, Zita CHOVANCOVÁ, Louis BOON, Marcela VLKOVÁ and Menno C. van ZELM. Absence of Surface IgD Does Not Impair Naive B Cell Homeostasis or Memory B Cell Formation in IGHD Haploinsufficient Humans. \textit{Journal of immunology}. Bethesda: American association of immunologists, 2018, vol.~201, No~7, p.~1928-1935. ISSN~0022-1767. Available from: https://dx.doi.org/10.4049/jimmunol.1800767.
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