Circadian rhythm of cardiac troponin I and its clinical impact
on the diagnostic accuracy for acute myocardial infarction

J 2018

Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction

WILDI, K., H. SINGEISEN, R. TWERENBOLD, P. BADERTSCHER, D. WUSSLER et. al.

Basic information

Original name

Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction

Authors

WILDI, K. (756 Switzerland), H. SINGEISEN (756 Switzerland), R. TWERENBOLD (756 Switzerland), P. BADERTSCHER (756 Switzerland), D. WUSSLER (756 Switzerland), L.J.J. KLINKENBERG (528 Netherlands), S.J.R. MEEX (528 Netherlands), T. NESTELBERGER (756 Switzerland), J. BOEDDINGHAUS (756 Switzerland), O. MIRO (724 Spain), F.J. MARTIN-SANCHEZ (724 Spain), B. MORAWIEC (616 Poland), P. MUZYK (616 Poland), Jiří PAŘENICA (203 Czech Republic, belonging to the institution), D.I. KELLER (756 Switzerland), N. GEIGY (756 Switzerland), E. POTLUKOVA (756 Switzerland), Z. SABTI (756 Switzerland), N. KOZHUHAROV (756 Switzerland), C. PUELACHER (756 Switzerland), J.D. de LAVALLAZ (756 Switzerland), M.R. GIMENEZ (756 Switzerland), S. SHRESTHA (756 Switzerland), G. MARZANO (756 Switzerland), K. RENTSCH (756 Switzerland), S. OSSWALD (756 Switzerland), T. REICHLIN (756 Switzerland) and C. MUELLER (756 Switzerland, guarantor)

Edition

International Journal of Cardiology, Clare, Elsevier Ireland Ltd. 2018, 0167-5273

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30201 Cardiac and Cardiovascular systems

Country of publisher

Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.471

RIV identification code

RIV/00216224:14110/18:00104226

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.ijcard.2018.05.136

UT WoS

000444609000003

Keywords in English

Acute myocardial infarction; Diagnosis; High-sensitivity cardiac troponin I; Circadian rhythm

Abstract

V originále

Background: High-sensitivity cardiac troponin T (hs-cTnT) blood concentrationswere shown to exhibit a diurnal rhythm, characterized by gradually decreasing concentrations throughout daytime, rising concentrations during nighttime and peak concentrations in the morning. We aimed to investigate whether this also applies to (h)s-cTnI assays and whether it would affect diagnostic accuracy for acute myocardial infarction (AMI). Methods: Blood concentrations of cTnI were measured at presentation and after 1 h using four different cTnI assays: three commonly used sensitive (s-cTnI Architect, Ultra and Accu) and one experimental high-sensitivity assay (hs-cTnI Accu) in a prospective multicenter diagnostic study of patients presenting to the emergency department with suspected AMI. These concentrations and their diagnostic accuracy for AMI (quantified by the area under the curve (AUC)) were compared between morning (11 p.m. to 2 p.m.) and evening (2 p.m. to 11 p. m.) presenters. Results: Among 2601 patients, AMI was the final diagnosis in 17.6% of patients. Concentrations of (h) s-cTnI as measured using all four assayswere comparable in patients presenting in themorning versus patients presenting in the evening. Diagnostic accuracy for AMI of all four (h) s-cTnI assays were high and comparable between patients presenting in the morning versus presenting in the evening (AUC at presentation: 0.90 vs 0.93 for s-cTnI Architect; 0.91 vs 0.94 for s-cTnI Ultra; 0.89 vs 0.94 for s-cTnI Accu; 0.91 vs 0.94 for hs-cTnI Accu). Conclusions: Cardiac TnI does not seemto express a diurnal rhythm. Diagnostic accuracy for AMI is very high and does not differ with time of presentation. Clinical trial registration: NCT00470587, http://clinicaltrials.gov/show/NCT00470587 (c) 2018 Elsevier B.V. All rights reserved.

Citovat

WILDI, K., H. SINGEISEN, R. TWERENBOLD, P. BADERTSCHER, D. WUSSLER, L.J.J. KLINKENBERG, S.J.R. MEEX, T. NESTELBERGER, J. BOEDDINGHAUS, O. MIRO, F.J. MARTIN-SANCHEZ, B. MORAWIEC, P. MUZYK, Jiří PAŘENICA, D.I. KELLER, N. GEIGY, E. POTLUKOVA, Z. SABTI, N. KOZHUHAROV, C. PUELACHER, J.D. de LAVALLAZ, M.R. GIMENEZ, S. SHRESTHA, G. MARZANO, K. RENTSCH, S. OSSWALD, T. REICHLIN and C. MUELLER. Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction. International Journal of Cardiology. Clare: Elsevier Ireland Ltd., 2018, vol. 270, NOV 1 2018, p. 14-20. ISSN 0167-5273. Available from: https://dx.doi.org/10.1016/j.ijcard.2018.05.136.

@article{1456237,
   author = {Wildi, K. and Singeisen, H. and Twerenbold, R. and Badertscher, P. and Wussler, D. and Klinkenberg, L.J.J. and Meex, S.J.R. and Nestelberger, T. and Boeddinghaus, J. and Miro, O. and MartinandSanchez, F.J. and Morawiec, B. and Muzyk, P. and Pařenica, Jiří and Keller, D.I. and Geigy, N. and Potlukova, E. and Sabti, Z. and Kozhuharov, N. and Puelacher, C. and Lavallaz, J.D. de and Gimenez, M.R. and Shrestha, S. and Marzano, G. and Rentsch, K. and Osswald, S. and Reichlin, T. and Mueller, C.},
   article_location = {Clare},
   article_number = {NOV 1 2018},
   doi = {http://dx.doi.org/10.1016/j.ijcard.2018.05.136},
   keywords = {Acute myocardial infarction; Diagnosis; High-sensitivity cardiac troponin I; Circadian rhythm},
   language = {eng},
   issn = {0167-5273},
   journal = {International Journal of Cardiology},
   title = {Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction},
   volume = {270},
   year = {2018}
}

TY  - JOUR
ID  - 1456237
AU  - Wildi, K. - Singeisen, H. - Twerenbold, R. - Badertscher, P. - Wussler, D. - Klinkenberg, L.J.J. - Meex, S.J.R. - Nestelberger, T. - Boeddinghaus, J. - Miro, O. - Martin-Sanchez, F.J. - Morawiec, B. - Muzyk, P. - Pařenica, Jiří - Keller, D.I. - Geigy, N. - Potlukova, E. - Sabti, Z. - Kozhuharov, N. - Puelacher, C. - Lavallaz, J.D. de - Gimenez, M.R. - Shrestha, S. - Marzano, G. - Rentsch, K. - Osswald, S. - Reichlin, T. - Mueller, C.
PY  - 2018
TI  - Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction
JF  - International Journal of Cardiology
VL  - 270
IS  - NOV 1 2018
SP  - 14-20
EP  - 14-20
PB  - Elsevier Ireland Ltd.
SN  - 01675273
KW  - Acute myocardial infarction
KW  - Diagnosis
KW  - High-sensitivity cardiac troponin I
KW  - Circadian rhythm
N2  - Background: High-sensitivity cardiac troponin T (hs-cTnT) blood concentrationswere shown to exhibit a diurnal rhythm, characterized by gradually decreasing concentrations throughout daytime, rising concentrations during nighttime and peak concentrations in the morning. We aimed to investigate whether this also applies to (h)s-cTnI assays and whether it would affect diagnostic accuracy for acute myocardial infarction (AMI). Methods: Blood concentrations of cTnI were measured at presentation and after 1 h using four different cTnI assays: three commonly used sensitive (s-cTnI Architect, Ultra and Accu) and one experimental high-sensitivity assay (hs-cTnI Accu) in a prospective multicenter diagnostic study of patients presenting to the emergency department with suspected AMI. These concentrations and their diagnostic accuracy for AMI (quantified by the area under the curve (AUC)) were compared between morning (11 p.m. to 2 p.m.) and evening (2 p.m. to 11 p. m.) presenters. Results: Among 2601 patients, AMI was the final diagnosis in 17.6% of patients. Concentrations of (h) s-cTnI as measured using all four assayswere comparable in patients presenting in themorning versus patients presenting in the evening. Diagnostic accuracy for AMI of all four (h) s-cTnI assays were high and comparable between patients presenting in the morning versus presenting in the evening (AUC at presentation: 0.90 vs 0.93 for s-cTnI Architect; 0.91 vs 0.94 for s-cTnI Ultra; 0.89 vs 0.94 for s-cTnI Accu; 0.91 vs 0.94 for hs-cTnI Accu). Conclusions: Cardiac TnI does not seemto express a diurnal rhythm. Diagnostic accuracy for AMI is very high and does not differ with time of presentation. Clinical trial registration: NCT00470587, http://clinicaltrials.gov/show/NCT00470587 (c) 2018 Elsevier B.V. All rights reserved.
ER  -

WILDI, K., H. SINGEISEN, R. TWERENBOLD, P. BADERTSCHER, D. WUSSLER, L.J.J. KLINKENBERG, S.J.R. MEEX, T. NESTELBERGER, J. BOEDDINGHAUS, O. MIRO, F.J. MARTIN-SANCHEZ, B. MORAWIEC, P. MUZYK, Jiří PAŘENICA, D.I. KELLER, N. GEIGY, E. POTLUKOVA, Z. SABTI, N. KOZHUHAROV, C. PUELACHER, J.D. de LAVALLAZ, M.R. GIMENEZ, S. SHRESTHA, G. MARZANO, K. RENTSCH, S. OSSWALD, T. REICHLIN and C. MUELLER. Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction. \textit{International Journal of Cardiology}. Clare: Elsevier Ireland Ltd., 2018, vol.~270, NOV 1 2018, p.~14-20. ISSN~0167-5273. Available from: https://dx.doi.org/10.1016/j.ijcard.2018.05.136.

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