Spondylodiscitis is a term used to indicate infection of the intervertebral disc and osteomyelitis of the adjacent vertebrae. It is a relatively rare disease in developed countries, representing 3-5% of all skeletal infections. The inflammation is localized most often in the lumbar spine. Neurological deficits are present in 30-50% of patients with spondylodiscitis. Frequent occurrence of chronic back pain in the general population as well as negative findings on plain radiography in the earlier stages of the disease oftentimes make the diagnosis difficult and delayed. A conservative therapeutic approach consists of antibiotic therapy which may be reduced to six weeks in uncomplicated cases according to new data. Compression of neural structures with neurological deficits, spinal instability, and failure of conservative treatment are all indications for surgical intervention. We are presenting a set of 11 patients with spondylodiscitis from which we selected 3 interesting case reports in order to demonstrate the various courses of the disease.