Prognostic value of cystatin C in relation to other markers of
renal function in early prediction of hospital mortality and
major cardiac adverse events in patients with ST elevation
myocardial infarction treated by primary percutaneous coronary
intervention

J 2018

Prognostic value of cystatin C in relation to other markers of renal function in early prediction of hospital mortality and major cardiac adverse events in patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention

PŘEČEK, Jan, Martin HUTYRA, Martin SNĚHOTA, Jiří JARKOVSKÝ, Tomáš ADAM et. al.

Basic information

Original name

Prognostic value of cystatin C in relation to other markers of renal function in early prediction of hospital mortality and major cardiac adverse events in patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention

Authors

PŘEČEK, Jan (203 Czech Republic), Martin HUTYRA (203 Czech Republic, guarantor), Martin SNĚHOTA (203 Czech Republic), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Tomáš ADAM, Miloslav ŠPAČEK (203 Czech Republic), Štěpán HUDEC (203 Czech Republic) and Miloš TÁBORSKÝ (203 Czech Republic)

Edition

Cor et Vasa, AMSTERDAM, ELSEVIER SCIENCE BV, 2018, 0010-8650

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10103 Statistics and probability

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/18:00104277

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1016/j.crvasa.2017.11.005

UT WoS

000442902500003

Keywords in English

ST elevation myocardial infarction; Hospital mortality; Major adverse cardiac events; Cystatin C; GRACE score

Abstract

V originále

Introduction: Cystatin C has been implicated as a prognostic marker in cardiovascular diseases. The aim of prospective study was to evaluate the benefits of measuring cystatin C for prognostic stratification to predict hospital mortality and the rates of major cardiac adverse events (MACE) in ST elevation myocardial infarction (STEMI) patients and to compare cystatin C to other markers of renal function and Global Registry of Acute Coronary Events (GRACE) score. Methods: A total of 659 consecutive patients (479 men, mean age 65 years) from a prospective study on acute STEMI treated by primary percutaneous coronary intervention (PCI) were evaluated. Standard laboratory tests including cystatin C, troponin T, NT-terminal fragment of brain natriuretic peptide (NT-proBNP), markers of renal function were assessed on admission in all patients. Using c-statistic, the ability of cystatin C, other biomarkers and GRACE score to predict hospital mortality and MACE (acute coronary syndrome recurrence, stroke event, definite in-stent thrombosis and mortality) rate was evaluated. Results: All-cause hospital mortality and MACE occurrence were 4% (n = 26) resp. 6.8% (n = 45). Cystatin C, creatinine, urea, glomerular filtration rate, troponin T, NT-proBNP and GRACE on admission were identified as significant prognostic risk markers. Serum cystatin C level and GRACE score were significantly higher in non-survivors (1.65 +/- 0.91 vs. 0.97 +/- 0.41 mg/mL; P < 0.001 resp. 138 +/- 43 vs. 99 +/- 31; P < 0.001). The area under the curve (AUC) values for mortality and MACE rate prediction for cystatin C and GRACE score were 0.83 and 0.88, respectively 0.66 and 0.72 (all P < 0.001) with optimal cut-off values of 1.3 mg/mL for cystatin C and 136 for GRACE score. Cystatin C above cut-off > 1.30 mg/L was associated with the highest adjusted odds ratio (OR) 3.85 (95% confidence interval 2.36-6.38; P < 0.001), and predicted in-hospital mortality with 77% sensitivity and 86% specificity. The addition of cystatin C to the GRACE score (OR 1.05, 95% confidence interval 1.04-1.07; P < 0.001) was not significantly associated with improved risk stratification. Conclusions: Cystatin C is a predictor of early outcome comparable with the GRACE score in patients with STEMI. (c) 2017 The Czech Society of Cardiology. Published by Elsevier Sp. zo.o. All rights reserved.

Citovat

PŘEČEK, Jan, Martin HUTYRA, Martin SNĚHOTA, Jiří JARKOVSKÝ, Tomáš ADAM, Miloslav ŠPAČEK, Štěpán HUDEC and Miloš TÁBORSKÝ. Prognostic value of cystatin C in relation to other markers of renal function in early prediction of hospital mortality and major cardiac adverse events in patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention. Cor et Vasa. AMSTERDAM: ELSEVIER SCIENCE BV, 2018, vol. 60, No 4, p. "E352"-"E360", 9 pp. ISSN 0010-8650. Available from: https://dx.doi.org/10.1016/j.crvasa.2017.11.005.

@article{1458776,
   author = {Přeček, Jan and Hutyra, Martin and Sněhota, Martin and Jarkovský, Jiří and Adam, Tomáš and Špaček, Miloslav and Hudec, Štěpán and Táborský, Miloš},
   article_location = {AMSTERDAM},
   article_number = {4},
   doi = {http://dx.doi.org/10.1016/j.crvasa.2017.11.005},
   keywords = {ST elevation myocardial infarction; Hospital mortality; Major adverse cardiac events; Cystatin C; GRACE score},
   language = {eng},
   issn = {0010-8650},
   journal = {Cor et Vasa},
   title = {Prognostic value of cystatin C in relation to other markers of renal function in early prediction of hospital mortality and major cardiac adverse events in patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention},
   volume = {60},
   year = {2018}
}

TY  - JOUR
ID  - 1458776
AU  - Přeček, Jan - Hutyra, Martin - Sněhota, Martin - Jarkovský, Jiří - Adam, Tomáš - Špaček, Miloslav - Hudec, Štěpán - Táborský, Miloš
PY  - 2018
TI  - Prognostic value of cystatin C in relation to other markers of renal function in early prediction of hospital mortality and major cardiac adverse events in patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention
JF  - Cor et Vasa
VL  - 60
IS  - 4
SP  - "E352"-"E360"
EP  - "E352"-"E360"
PB  - ELSEVIER SCIENCE BV
SN  - 00108650
KW  - ST elevation myocardial infarction
KW  - Hospital mortality
KW  - Major adverse cardiac events
KW  - Cystatin C
KW  - GRACE score
N2  - Introduction: Cystatin C has been implicated as a prognostic marker in cardiovascular diseases. The aim of prospective study was to evaluate the benefits of measuring cystatin C for prognostic stratification to predict hospital mortality and the rates of major cardiac adverse events (MACE) in ST elevation myocardial infarction (STEMI) patients and to compare cystatin C to other markers of renal function and Global Registry of Acute Coronary Events (GRACE) score. Methods: A total of 659 consecutive patients (479 men, mean age 65 years) from a prospective study on acute STEMI treated by primary percutaneous coronary intervention (PCI) were evaluated. Standard laboratory tests including cystatin C, troponin T, NT-terminal fragment of brain natriuretic peptide (NT-proBNP), markers of renal function were assessed on admission in all patients. Using c-statistic, the ability of cystatin C, other biomarkers and GRACE score to predict hospital mortality and MACE (acute coronary syndrome recurrence, stroke event, definite in-stent thrombosis and mortality) rate was evaluated. Results: All-cause hospital mortality and MACE occurrence were 4% (n = 26) resp. 6.8% (n = 45). Cystatin C, creatinine, urea, glomerular filtration rate, troponin T, NT-proBNP and GRACE on admission were identified as significant prognostic risk markers. Serum cystatin C level and GRACE score were significantly higher in non-survivors (1.65 +/- 0.91 vs. 0.97 +/- 0.41 mg/mL; P < 0.001 resp. 138 +/- 43 vs. 99 +/- 31; P < 0.001). The area under the curve (AUC) values for mortality and MACE rate prediction for cystatin C and GRACE score were 0.83 and 0.88, respectively 0.66 and 0.72 (all P < 0.001) with optimal cut-off values of 1.3 mg/mL for cystatin C and 136 for GRACE score. Cystatin C above cut-off > 1.30 mg/L was associated with the highest adjusted odds ratio (OR) 3.85 (95% confidence interval 2.36-6.38; P < 0.001), and predicted in-hospital mortality with 77% sensitivity and 86% specificity. The addition of cystatin C to the GRACE score (OR 1.05, 95% confidence interval 1.04-1.07; P < 0.001) was not significantly associated with improved risk stratification. Conclusions: Cystatin C is a predictor of early outcome comparable with the GRACE score in patients with STEMI. (c) 2017 The Czech Society of Cardiology. Published by Elsevier Sp. zo.o. All rights reserved.
ER  -

PŘEČEK, Jan, Martin HUTYRA, Martin SNĚHOTA, Jiří JARKOVSKÝ, Tomáš ADAM, Miloslav ŠPAČEK, Štěpán HUDEC and Miloš TÁBORSKÝ. Prognostic value of cystatin C in relation to other markers of renal function in early prediction of hospital mortality and major cardiac adverse events in patients with ST elevation myocardial infarction treated by primary percutaneous coronary intervention. \textit{Cor et Vasa}. AMSTERDAM: ELSEVIER SCIENCE BV, 2018, vol.~60, No~4, p.~''E352''-''E360'', 9 pp. ISSN~0010-8650. Available from: https://dx.doi.org/10.1016/j.crvasa.2017.11.005.

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