| BOSÁK, Juraj, Lenka MICENKOVÁ, Matěj HRALA, Katarína POMORSKÁ, Michaela BOSÁKOVÁ, Pavel KREJČÍ, Eduard GÖPFERT, Martin FALDYNA and David ŠMAJS. Colicin F-Y inhibits pathogenic Yersinia enterocolitica in mice. Scientific reports. London: NATURE PUBLISHING GROUP, 2018, vol. 8, No 12242, p. 1-12. ISSN 2045-2322. Available from: https://dx.doi.org/10.1038/s41598-018-30729-7. |
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@article{1461576,
author = {Bosák, Juraj and Micenková, Lenka and Hrala, Matěj and Pomorská, Katarína and Bosáková, Michaela and Krejčí, Pavel and Göpfert, Eduard and Faldyna, Martin and Šmajs, David},
article_location = {London},
article_number = {12242},
doi = {http://dx.doi.org/10.1038/s41598-018-30729-7},
keywords = {Yersinia enterocolitica; Colicin F-Y},
language = {eng},
issn = {2045-2322},
journal = {Scientific reports},
title = {Colicin F-Y inhibits pathogenic Yersinia enterocolitica in mice},
volume = {8},
year = {2018}
}
TY - JOUR
ID - 1461576
AU - Bosák, Juraj - Micenková, Lenka - Hrala, Matěj - Pomorská, Katarína - Bosáková, Michaela - Krejčí, Pavel - Göpfert, Eduard - Faldyna, Martin - Šmajs, David
PY - 2018
TI - Colicin F-Y inhibits pathogenic Yersinia enterocolitica in mice
JF - Scientific reports
VL - 8
IS - 12242
SP - 1-12
EP - 1-12
PB - NATURE PUBLISHING GROUP
SN - 20452322
KW - Yersinia enterocolitica
KW - Colicin F-Y
N2 - Yersiniosis belongs to the common foodborne diseases around the world, and frequently manifests as diarrhea that can be treated with probiotics. Colicin F-Y is an antibacterial agent produced by bacteria and it is capable of specific growth inhibition of Yersinia enterocolitica, the causative agent of gastrointestinal yersiniosis. In this study, recombinant E. coli producing colicin F-Y were constructed, using both known probiotic strains EcH22 and EcColinfant, and the newly isolated murine strains Ec1127 and Ec1145. All E. coli strains producing colicin FY inhibited growth of pathogenic Y. enterocolitica during co-cultivation in vitro. In dysbiotic mice treated with streptomycin, E. coli strains producing colicin F-Y inhibited progression of Y. enterocolitica infections. This growth inhibition was not observed in mice with normal gut microflora, likely due to insufficient colonization capacity of E. coli strains and/or due to spatial differences in intestinal niches. Isogenic Y. enterocolitica producing colicin F-Y was constructed and shown to inhibit pathogenic Y. enterocolitica in mice with normal microflora. Evidence of in vivo antimicrobial activity of colicin F-Y may have utility in the treatment of Y. enterocolitica infections.
ER -
BOSÁK, Juraj, Lenka MICENKOVÁ, Matěj HRALA, Katarína POMORSKÁ, Michaela BOSÁKOVÁ, Pavel KREJČÍ, Eduard GÖPFERT, Martin FALDYNA and David ŠMAJS. Colicin F-Y inhibits pathogenic Yersinia enterocolitica in mice. \textit{Scientific reports}. London: NATURE PUBLISHING GROUP, 2018, vol.~8, No~12242, p.~1-12. ISSN~2045-2322. Available from: https://dx.doi.org/10.1038/s41598-018-30729-7.
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