| BENEJ, Michal, Iva ZAMBO, Ondřej BILEK a Ivan ČAPOV. SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL DIAGNOSTIC PITFALL. POLISH JOURNAL OF PATHOLOGY. CRACOW: VESALIUS UNIV MEDICAL PUBL, roč. 68, č. 4, s. 354-358. ISSN 1233-9687. doi:10.5114/pjp.2017.73931. 2017. |
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@article{1466078,
author = {Benej, Michal and Zambo, Iva and Bilek, Ondřej and Čapov, Ivan},
article_location = {CRACOW},
article_number = {4},
doi = {http://dx.doi.org/10.5114/pjp.2017.73931},
keywords = {neuroendocrine tumor; malignant paraganglioma; hereditary syndromes; thyroid transcription factor 1},
language = {eng},
issn = {1233-9687},
journal = {POLISH JOURNAL OF PATHOLOGY},
title = {SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL DIAGNOSTIC PITFALL},
volume = {68},
year = {2017}
}
TY - JOUR
ID - 1466078
AU - Benej, Michal - Zambo, Iva - Bilek, Ondřej - Čapov, Ivan
PY - 2017
TI - SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL DIAGNOSTIC PITFALL
JF - POLISH JOURNAL OF PATHOLOGY
VL - 68
IS - 4
SP - 354-358
EP - 354-358
PB - VESALIUS UNIV MEDICAL PUBL
SN - 12339687
KW - neuroendocrine tumor
KW - malignant paraganglioma
KW - hereditary syndromes
KW - thyroid transcription factor 1
N2 - Metastatic extra-adrenal paragangliomas are very rare and can represent diagnostic challenges. We report a case of 69-year-old man with a tumor of the right shoulder. Histologic and immunohistochemical examinations confirmed the diagnosis of paraganglioma. Surprisingly, tumor cells were diffusely thyroid transcription factor 1 (TTF-1) positive. Succinate dehydrogenase complex subunit B (SDHB) deficiency has not been detected. Inherited syndromes associated with paragangliomas were ruled out. The primary tumor was identified in the mediastinum. This is the first report of TTF-1 expression in paraganglioma. To avoid misdiagnosis, careful clinical and pathological examination of any tumor with organoid growths pattern is necessary.
ER -
BENEJ, Michal, Iva ZAMBO, Ondřej BILEK a Ivan ČAPOV. SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL DIAGNOSTIC PITFALL. \textit{POLISH JOURNAL OF PATHOLOGY}. CRACOW: VESALIUS UNIV MEDICAL PUBL, roč.~68, č.~4, s.~354-358. ISSN~1233-9687. doi:10.5114/pjp.2017.73931. 2017.
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