BENEJ, Michal, Iva ZAMBO, Ondřej BILEK and Ivan ČAPOV. SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL DIAGNOSTIC PITFALL. POLISH JOURNAL OF PATHOLOGY. CRACOW: VESALIUS UNIV MEDICAL PUBL, 2017, vol. 68, No 4, p. 354-358. ISSN 1233-9687. Available from: https://dx.doi.org/10.5114/pjp.2017.73931.
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Basic information
Original name SOFT TISSUE METASTASIS OF MEDIASTINAL NON-FUNCTIONING PARAGANGLIOMA WITH UNUSUAL TTF-1 EXPRESSION: A POTENTIAL DIAGNOSTIC PITFALL
Authors BENEJ, Michal (703 Slovakia, belonging to the institution), Iva ZAMBO (203 Czech Republic, guarantor), Ondřej BILEK and Ivan ČAPOV (203 Czech Republic, belonging to the institution).
Edition POLISH JOURNAL OF PATHOLOGY, CRACOW, VESALIUS UNIV MEDICAL PUBL, 2017, 1233-9687.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30109 Pathology
Country of publisher Poland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.865
RIV identification code RIV/00216224:14110/17:00104426
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.5114/pjp.2017.73931
UT WoS 000428126800012
Keywords in English neuroendocrine tumor; malignant paraganglioma; hereditary syndromes; thyroid transcription factor 1
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 9/11/2018 11:57.
Abstract
Metastatic extra-adrenal paragangliomas are very rare and can represent diagnostic challenges. We report a case of 69-year-old man with a tumor of the right shoulder. Histologic and immunohistochemical examinations confirmed the diagnosis of paraganglioma. Surprisingly, tumor cells were diffusely thyroid transcription factor 1 (TTF-1) positive. Succinate dehydrogenase complex subunit B (SDHB) deficiency has not been detected. Inherited syndromes associated with paragangliomas were ruled out. The primary tumor was identified in the mediastinum. This is the first report of TTF-1 expression in paraganglioma. To avoid misdiagnosis, careful clinical and pathological examination of any tumor with organoid growths pattern is necessary.
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