Detailed Information on Publication Record
2018
Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to AJCC 8th edition
GURÍN, Dominik, Marek SLÁVIK, Markéta HERMANOVÁ, Tetiana SHATOKHINA, Jiří ŠÁNA et. al.Basic information
Original name
Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to AJCC 8th edition
Authors
GURÍN, Dominik (203 Czech Republic, belonging to the institution), Marek SLÁVIK (703 Slovakia, belonging to the institution), Markéta HERMANOVÁ (203 Czech Republic, belonging to the institution), Tetiana SHATOKHINA (804 Ukraine, belonging to the institution), Jiří ŠÁNA (203 Czech Republic, belonging to the institution), Tomáš KAZDA (203 Czech Republic, belonging to the institution), Iveta SELINGEROVÁ (203 Czech Republic, belonging to the institution), Parwez AHMAD (356 India, belonging to the institution), Pavel SMILEK (203 Czech Republic, belonging to the institution), Zuzana HORÁKOVÁ (203 Czech Republic, belonging to the institution), Michal HENDRYCH (203 Czech Republic, belonging to the institution), Pavel ŠLAMPA (203 Czech Republic, belonging to the institution) and Ondřej SLABÝ (203 Czech Republic, belonging to the institution)
Edition
JOURNAL OF ORAL PATHOLOGY & MEDICINE, HOBOKEN, WILEY, 2018, 0904-2512
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30109 Pathology
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.030
RIV identification code
RIV/00216224:14110/18:00106945
Organization unit
Faculty of Medicine
UT WoS
000446836900009
Keywords in English
CD44; combined immunoprofiles; EGFR; OPSCC; p16
Tags
International impact, Reviewed
Změněno: 7/3/2019 16:36, Mgr. Pavla Foltynová, Ph.D.
Abstract
V originále
ObjectivesTo examine combined immunoprofiles of epidermal growth factor receptor (EGFR), CD44, and p16 in oropharyngeal squamous cell carcinoma (OPSCC) and to correlate them with radiotherapy treatment outcomes and clinicopathological parameters. Prognostic impact of the American Joint Committee on Cancer (AJCC) 8th edition staging system in comparison with 7th edition was analyzed. MethodsThe study included 77 OPSCC patients treated by definitive intensity-modulated radiotherapy (IMRT). Clinical staging was assessed according to the AJCC, both 7th and 8th edition. Immunohistochemical (IHC) analysis of CD44 and EGFR was performed on primary biopsy tumor tissues. To evaluate the HPV status, IHC detection of p16 was employed. ResultsThe AJCC 8th edition staging system revealed correlations between overall survival (OS), progression-free survival (PFS), locoregional control (LRC), and clinical stage. EGFR and CD44 positivity (+) and p16 negativity (-) were associated with clinical stage IV of the disease. CD44+ and EGFR+ OPSCC displayed worse OS and LRC, and these cases also showed the worst 3-year OS and LRC. Combined analysis of protein expressions identified an association between p16- and EGFR+, p16- and CD44+, EGFR+, and CD44+. Combined immunoprofiles CD44+/p16-, EGFR+/p16-, and EGFR+/CD44+ were associated with worst OS and LRC. ConclusionsCombined immunoprofiles of p16, EGFR, and CD44 might provide valuable prognostic and predictive information for the individual OPSCC patients, especially in terms of response to IMRT and prediction of treatment outcomes. Application of the AJCC 8th edition staging for HPV+ OPSCC proved to improve hazard discrimination and prognostication of OPSCC.
Links
| NV15-31627A, research and development project |
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