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@article{1466236,
author = {Gurín, Dominik and Slávik, Marek and Hermanová, Markéta and Shatokhina, Tetiana and Šána, Jiří and Kazda, Tomáš and Selingerová, Iveta and Ahmad, Parwez and Smilek, Pavel and Horáková, Zuzana and Hendrych, Michal and Šlampa, Pavel and Slabý, Ondřej},
article_location = {HOBOKEN},
article_number = {9},
doi = {http://dx.doi.org/10.1111/jop.12772},
keywords = {CD44; combined immunoprofiles; EGFR; OPSCC; p16},
language = {eng},
issn = {0904-2512},
journal = {JOURNAL OF ORAL PATHOLOGY & MEDICINE},
title = {Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to AJCC 8th edition},
volume = {47},
year = {2018}
}
TY - JOUR
ID - 1466236
AU - Gurín, Dominik - Slávik, Marek - Hermanová, Markéta - Shatokhina, Tetiana - Šána, Jiří - Kazda, Tomáš - Selingerová, Iveta - Ahmad, Parwez - Smilek, Pavel - Horáková, Zuzana - Hendrych, Michal - Šlampa, Pavel - Slabý, Ondřej
PY - 2018
TI - Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to AJCC 8th edition
JF - JOURNAL OF ORAL PATHOLOGY & MEDICINE
VL - 47
IS - 9
SP - 864-872
EP - 864-872
PB - WILEY
SN - 09042512
KW - CD44
KW - combined immunoprofiles
KW - EGFR
KW - OPSCC
KW - p16
N2 - ObjectivesTo examine combined immunoprofiles of epidermal growth factor receptor (EGFR), CD44, and p16 in oropharyngeal squamous cell carcinoma (OPSCC) and to correlate them with radiotherapy treatment outcomes and clinicopathological parameters. Prognostic impact of the American Joint Committee on Cancer (AJCC) 8th edition staging system in comparison with 7th edition was analyzed. MethodsThe study included 77 OPSCC patients treated by definitive intensity-modulated radiotherapy (IMRT). Clinical staging was assessed according to the AJCC, both 7th and 8th edition. Immunohistochemical (IHC) analysis of CD44 and EGFR was performed on primary biopsy tumor tissues. To evaluate the HPV status, IHC detection of p16 was employed. ResultsThe AJCC 8th edition staging system revealed correlations between overall survival (OS), progression-free survival (PFS), locoregional control (LRC), and clinical stage. EGFR and CD44 positivity (+) and p16 negativity (-) were associated with clinical stage IV of the disease. CD44+ and EGFR+ OPSCC displayed worse OS and LRC, and these cases also showed the worst 3-year OS and LRC. Combined analysis of protein expressions identified an association between p16- and EGFR+, p16- and CD44+, EGFR+, and CD44+. Combined immunoprofiles CD44+/p16-, EGFR+/p16-, and EGFR+/CD44+ were associated with worst OS and LRC. ConclusionsCombined immunoprofiles of p16, EGFR, and CD44 might provide valuable prognostic and predictive information for the individual OPSCC patients, especially in terms of response to IMRT and prediction of treatment outcomes. Application of the AJCC 8th edition staging for HPV+ OPSCC proved to improve hazard discrimination and prognostication of OPSCC.
ER -
GURÍN, Dominik, Marek SLÁVIK, Markéta HERMANOVÁ, Tetiana SHATOKHINA, Jiří ŠÁNA, Tomáš KAZDA, Iveta SELINGEROVÁ, Parwez AHMAD, Pavel SMILEK, Zuzana HORÁKOVÁ, Michal HENDRYCH, Pavel ŠLAMPA and Ondřej SLABÝ. Prognostic impact of combined immunoprofiles in oropharyngeal squamous cell carcinoma patients with respect to AJCC 8th edition. \textit{JOURNAL OF ORAL PATHOLOGY \&{}amp; MEDICINE}. HOBOKEN: WILEY, 2018, vol.~47, No~9, p.~864-872. ISSN~0904-2512. Available from: https://dx.doi.org/10.1111/jop.12772.
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