| BOŘILOVÁ LINHARTOVÁ, Petra, Denisa KAVŘÍKOVÁ, Marie TOMANDLOVÁ, Hana POSKEROVÁ, Václav ŘEHKA, Ladislav DUŠEK and Lydie IZAKOVIČOVÁ HOLLÁ. Differences in Interleukin-8 Plasma Levels between Diabetic Patients and Healthy Individuals Independently on Their Periodontal Status. International Journal of Molecular Sciences. Basel, Switzerland: MDPI AG, 2018, vol. 19, No 10, p. 1-17. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms19103214. |
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@article{1468996,
author = {Bořilová Linhartová, Petra and Kavříková, Denisa and Tomandlová, Marie and Poskerová, Hana and Řehka, Václav and Dušek, Ladislav and Izakovičová Hollá, Lydie},
article_location = {Basel, Switzerland},
article_number = {10},
doi = {http://dx.doi.org/10.3390/ijms19103214},
keywords = {interleukin-8; chemokines; plasma; polymorphism; chronic periodontitis; diabetes mellitus},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Differences in Interleukin-8 Plasma Levels between Diabetic Patients and Healthy Individuals Independently on Their Periodontal Status},
volume = {19},
year = {2018}
}
TY - JOUR
ID - 1468996
AU - Bořilová Linhartová, Petra - Kavříková, Denisa - Tomandlová, Marie - Poskerová, Hana - Řehka, Václav - Dušek, Ladislav - Izakovičová Hollá, Lydie
PY - 2018
TI - Differences in Interleukin-8 Plasma Levels between Diabetic Patients and Healthy Individuals Independently on Their Periodontal Status
JF - International Journal of Molecular Sciences
VL - 19
IS - 10
SP - 1-17
EP - 1-17
PB - MDPI AG
SN - 14220067
KW - interleukin-8
KW - chemokines
KW - plasma
KW - polymorphism
KW - chronic periodontitis
KW - diabetes mellitus
N2 - Chronic periodontitis (CP) and diabetes mellitus (DM) involve several aspects of immune functions, including neutrophil activity and cytokine biology. Considering the critical function of chemokine interleukin-8 (IL-8) in the inflammatory process, the aims of this study were to determine: (i) IL-8 plasma levels; (ii) IL-8 (-251A/T, rs4073) and its receptor 2 (CXCR2, +1208C/T, rs1126579) polymorphisms, and (iii) the presence of the selected periodontal bacteria in types 1 and 2 DM patients (T1DM and T2DM) and systemically healthy controls (HC) with known periodontal status. This case-control study comprises of 153 unrelated individuals: 36/44 patients suffering from T1DM+CP/T2DM+CP and 32/41 from HC+CP/non-periodontitis HC. Both the clinical and biochemical parameters were monitored. The genotypes were determined using qPCR, IL-8 plasma levels were measured using an ELISA kit. Subgingival bacterial colonization was analyzed with a DNA microarray detection kit. The IL-8 plasma levels differed significantly between non-periodontitis HC and T1DM+CP/T2DM+CP patients (P < 0.01). Even in HC+CP, IL-8 concentrations were significantly lower than in T1DM+CP/T2DM+CP patients (P 0.05). No significant associations between the IL-8 plasma levels and the studied IL-8 and CXCR2 polymorphisms or the occurrence of selected periodontal bacteria (P > 0.05) were found. CP does not influence the circulating IL-8 levels. Patients with T1DM+CP/T2DM+CP had higher circulating IL-8 levels than HC+CP/non-periodontitis HC.
ER -
BOŘILOVÁ LINHARTOVÁ, Petra, Denisa KAVŘÍKOVÁ, Marie TOMANDLOVÁ, Hana POSKEROVÁ, Václav ŘEHKA, Ladislav DUŠEK and Lydie IZAKOVIČOVÁ HOLLÁ. Differences in Interleukin-8 Plasma Levels between Diabetic Patients and Healthy Individuals Independently on Their Periodontal Status. \textit{International Journal of Molecular Sciences}. Basel, Switzerland: MDPI AG, 2018, vol.~19, No~10, p.~1-17. ISSN~1422-0067. Available from: https://dx.doi.org/10.3390/ijms19103214.
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