Could overexpression of an ONCOGENE represent a good prognostic factor in cancer?

BENEŠ, Petr, Jan ŠMARDA and Lucia KNOPFOVÁ. Could overexpression of an ONCOGENE represent a good prognostic factor in cancer? In XIX. setkání biochemiků a molekulárních biologů, 13.-14. 11. 2018, Brno. 2018. ISBN 978-80-210-9069-9.

Basic information

• Original name: Could overexpression of an ONCOGENE represent a good prognostic factor in cancer?
• Authors: BENEŠ, Petr, Jan ŠMARDA and Lucia KNOPFOVÁ.
• Edition: XIX. setkání biochemiků a molekulárních biologů, 13.-14. 11. 2018, Brno, 2018.

Other information

• Type of outcome: Conference abstract
• Confidentiality degree: is not subject to a state or trade secret
• ISBN: 978-80-210-9069-9

Abstract

The c-Myb protein is a transcriptional regulator of stem cells maintenance in bone marrow, colon epithelia, and brain neurogenic niches. The pioneering research revealed that c-Myb is essential for normal hematopoiesis and identified it as important oncogene in various leukemias. The mechanism of its oncogenic function has been intensively studied in last decades and c-Myb is currently considered as a key regulator of balance between cell proliferation, differentiation and survival. Later studies found c-Myb overexpression in many carcinomas where its oncogenic function has been confirmed as well. Interestingly, we and others have recently shown that increased expression of c-Myb protein represents a good prognostic factor in breast and colon carcinomas. Our current research therefore aims to clarify this unusual phenomenon.

Links

• GJ17-08985Y, research and development project: Name: Prozánětlivá signalizace pod kontrolou proteinu c-Myb v bazálních prsních karcinomech

Investor: Czech Science Foundation

• NV18-07-00073, research and development project: Name: c-Myb a jeho transkripční program ve fyziologických a patologických osteogenních procesech

Investor: Ministry of Health of the CR