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@article{1473156,
author = {Kazda, Tomáš and Dziacky, Adam and Burkoň, Petr and Pospíšil, Petr and Slávik, Marek and Řehák, Zdeněk and Jančálek, Radim and Šlampa, Pavel and Slabý, Ondřej and Lakomý, Radek},
article_location = {LJUBLJANA},
article_number = {2},
doi = {http://dx.doi.org/10.2478/raon-2018-0023},
keywords = {glioblastoma; radiation therapy; controversy; target volumes; radiotherapy dosage},
language = {eng},
issn = {1318-2099},
journal = {RADIOLOGY AND ONCOLOGY},
title = {Radiotherapy of glioblastoma 15 years after the landmark Stupp's trial: more controversies than standards?},
volume = {52},
year = {2018}
}
TY - JOUR
ID - 1473156
AU - Kazda, Tomáš - Dziacky, Adam - Burkoň, Petr - Pospíšil, Petr - Slávik, Marek - Řehák, Zdeněk - Jančálek, Radim - Šlampa, Pavel - Slabý, Ondřej - Lakomý, Radek
PY - 2018
TI - Radiotherapy of glioblastoma 15 years after the landmark Stupp's trial: more controversies than standards?
JF - RADIOLOGY AND ONCOLOGY
VL - 52
IS - 2
SP - 121-128
EP - 121-128
PB - ASSOC RADIOLOGY & ONCOLOGY
SN - 13182099
KW - glioblastoma
KW - radiation therapy
KW - controversy
KW - target volumes
KW - radiotherapy dosage
N2 - Background. The current standard of care of glioblastoma, the most common primary brain tumor in adults, has remained unchanged for over a decade. Nevertheless, some improvements in patient outcomes have occurred as a consequence of modern surgery, improved radiotherapy and up-to-date management of toxicity. Patients from control arms (receiving standard concurrent chemoradiotherapy and adjuvant chemotherapy with temozolomide) of recent clinical trials achieve better outcomes compared to the median survival of 14.6 months reported in Stupp's landmark clinical trial in 2005. The approach to radiotherapy that emerged from Stupp's trial, which continues to be a basis for the current standard of care, is no longer applicable and there is a need to develop updated guidelines for radiotherapy within the daily clinical practice that address or at least acknowledge existing controversies in the planning of radiotherapy. The goal of this review is to provoke critical thinking about potentially controversial aspects in the radiotherapy of glioblastoma, including among others the issue of target definitions, simultaneously integrated boost technique, and hippocampal sparing. Conclusions. In conjunction with new treatment approaches such as tumor-treating fields (TTF) and immunotherapy, the role of adjuvant radiotherapy will be further defined. The personalized approach in daily radiotherapy practice is enabled with modern radiotherapy systems.
ER -
KAZDA, Tomáš, Adam DZIACKY, Petr BURKOŇ, Petr POSPÍŠIL, Marek SLÁVIK, Zdeněk ŘEHÁK, Radim JANČÁLEK, Pavel ŠLAMPA, Ondřej SLABÝ and Radek LAKOMÝ. Radiotherapy of glioblastoma 15 years after the landmark Stupp's trial: more controversies than standards? \textit{RADIOLOGY AND ONCOLOGY}. LJUBLJANA: ASSOC RADIOLOGY \&{}amp; ONCOLOGY, 2018, vol.~52, No~2, p.~121-128. ISSN~1318-2099. Available from: https://dx.doi.org/10.2478/raon-2018-0023.
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