Detailed Information on Publication Record
2018
Bejel in Cuba: molecular identification of Treponema pallidum subsp endemicum in patients diagnosed with venereal syphilis
NODA, A.A., Linda GRILLOVÁ, R. LIENHARD, O. BLANCO, I. RODRIGUEZ et. al.Basic information
Original name
Bejel in Cuba: molecular identification of Treponema pallidum subsp endemicum in patients diagnosed with venereal syphilis
Authors
NODA, A.A. (192 Cuba), Linda GRILLOVÁ (203 Czech Republic, belonging to the institution), R. LIENHARD (756 Switzerland), O. BLANCO (192 Cuba), I. RODRIGUEZ (192 Cuba) and David ŠMAJS (203 Czech Republic, guarantor, belonging to the institution)
Edition
Clinical Microbiology and Infection, NJ USA, WILEY-BLACKWELL, 2018, 1198-743X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30303 Infectious Diseases
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 6.425
RIV identification code
RIV/00216224:14110/18:00101381
Organization unit
Faculty of Medicine
UT WoS
000448188200019
Keywords in English
Bejel; Cuba; Diagnosis; Molecular typing; Treponema pallidum subsp endemicum
Tags
International impact, Reviewed
Změněno: 9/2/2019 21:05, Soňa Böhmová
Abstract
V originále
Objectives: Bejel, caused by Treponema pallidum subsp. endemicum (TEN), was until now considered as a non-venereal disease endemic in areas with hot and dry climates. This study has identified TEN in clinical samples from Cuban patients previously diagnosed with syphilis. Methods: We performed sequencing-based molecular typing on 92 samples from Cuban individuals diagnosed with syphilis. Moreover, to differentiate T. pallidum subspecies, multi-locus sequence analysis (MLSA) was designed and was applied to suspicious samples. Results: Nine samples, from six patients, had a nucleotide sequence similarity (at all typing loci) to the Bosnia A genome, which is the infectious agent of bejel. Additionally, MLSA clearly supported a TEN classification for the treponemal samples. Clinical and epidemiological data from the six patients also suggested sexual transmission of bejel as well as the endemicity of this rare treponematosis in Cuba. Conclusions: Molecular identification of Treponema pallidum subsp. endemicum, the agent of bejel, in Cuban patients diagnosed with syphilis indicates the clear limitations of a diagnosis based exclusively on serology, geographical occurrence, clinical symptoms and anamnestic data. This finding has important implications for Global Public Health Systems, including paradigm changes regarding the location of endemic outbreaks, clinical aspects and transmission of this neglected disease. (C) 2018 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
Links
| GA17-25455S, research and development project |
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| NV17-31333A, research and development project |
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