| CURGALI, K., S. TOTH, Z. JONECOVA, M. MARETTA, T. KALPAKIDIS, I. PETRISKOVA, M. KUSNIER, J. SOLTES, M. SVANA, M. CAPRNDA, D. DELEV, L. RODRIGO, E. MECHIROVA and Peter KRUŽLIAK. Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells. Acta Histochemica. Jena: Elsevier, vol. 120, No 1, p. 28-32. ISSN 0065-1281. doi:10.1016/j.acthis.2017.11.001. 2018. |
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@article{1473222,
author = {Curgali, K. and Toth, S. and Jonecova, Z. and Maretta, M. and Kalpakidis, T. and Petriskova, I. and Kusnier, M. and Soltes, J. and Svana, M. and Caprnda, M. and Delev, D. and Rodrigo, L. and Mechirova, E. and Kružliak, Peter},
article_location = {Jena},
article_number = {1},
doi = {http://dx.doi.org/10.1016/j.acthis.2017.11.001},
keywords = {CD68 positive cells; IL10; ischemia-reperfusion injury; QuercetinSmall intestine},
language = {eng},
issn = {0065-1281},
journal = {Acta Histochemica},
title = {Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells},
volume = {120},
year = {2018}
}
TY - JOUR
ID - 1473222
AU - Curgali, K. - Toth, S. - Jonecova, Z. - Maretta, M. - Kalpakidis, T. - Petriskova, I. - Kusnier, M. - Soltes, J. - Svana, M. - Caprnda, M. - Delev, D. - Rodrigo, L. - Mechirova, E. - Kružliak, Peter
PY - 2018
TI - Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells
JF - Acta Histochemica
VL - 120
IS - 1
SP - 28-32
EP - 28-32
PB - Elsevier
SN - 00651281
KW - CD68 positive cells
KW - IL10
KW - ischemia-reperfusion injury
KW - QuercetinSmall intestine
N2 - The aim of our study was to analyse the possible protective effect of quercetin application during the jejunal ischemia-reperfusion injury (IRI) in rats. Quercetin was administered intraperitoneally 30 min before 1 h ischemia of superior mesenteric artery with following 24 h lasting reperfusion period. The male specific pathogen-free (SPF) Charles River Wistar rats were used. In the group with applied quercetin, the significantly increased (p < 0.001) levels of anti-inflammatory cytokine IL10 were observed both in the blood serum and jejunal tissue. The improvement of the mucosal tissue morphology and proliferating and DNA repairing cell number measured by PCNA activity were recorded by more than 30% higher in the quercetin group. Simultaneously, significant elongation of the intestinal glands (p < 0.001) and increase in the number of CD68-positive cells in the lamina propria mucosae (p < 0.001) in comparison with control group were found. Based on our results, the preventive application of quercetin before induction of jejunal IRI stimulates faster jejunal mucosa restoration and it seems to have immunomodulatory and anti-inflammatory effects as well. CD68-positive macrophages could have crucial role in this process since they work as both growth factor and cytokine producers.
ER -
CURGALI, K., S. TOTH, Z. JONECOVA, M. MARETTA, T. KALPAKIDIS, I. PETRISKOVA, M. KUSNIER, J. SOLTES, M. SVANA, M. CAPRNDA, D. DELEV, L. RODRIGO, E. MECHIROVA and Peter KRUŽLIAK. Quercetin protects jejunal mucosa from experimental intestinal ischemia reperfusion injury by activation of CD68 positive cells. \textit{Acta Histochemica}. Jena: Elsevier, vol.~120, No~1, p.~28-32. ISSN~0065-1281. doi:10.1016/j.acthis.2017.11.001. 2018.
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