| KARNISOVA, Lucia, Ondrej HRADSKY, Kveta BLAHOVA, Filip FENCL, Zdeněk DOLEŽEL, Tomas ZAORAL and Jakub ZIEG. Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study. European journal of pediatrics. New York: Springer, 2018, vol. 177, No 12, p. 1837-1844. ISSN 0340-6199. Available from: https://dx.doi.org/10.1007/s00431-018-3255-2. |
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@article{1473308,
author = {Karnisova, Lucia and Hradsky, Ondrej and Blahova, Kveta and Fencl, Filip and Doležel, Zdeněk and Zaoral, Tomas and Zieg, Jakub},
article_location = {New York},
article_number = {12},
doi = {http://dx.doi.org/10.1007/s00431-018-3255-2},
keywords = {Complement; Hemolytic uremic syndrome; Shiga toxin-producing Escherichia coli; Renal replacement therapy},
language = {eng},
issn = {0340-6199},
journal = {European journal of pediatrics},
title = {Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study},
volume = {177},
year = {2018}
}
TY - JOUR
ID - 1473308
AU - Karnisova, Lucia - Hradsky, Ondrej - Blahova, Kveta - Fencl, Filip - Doležel, Zdeněk - Zaoral, Tomas - Zieg, Jakub
PY - 2018
TI - Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study
JF - European journal of pediatrics
VL - 177
IS - 12
SP - 1837-1844
EP - 1837-1844
PB - Springer
SN - 03406199
KW - Complement
KW - Hemolytic uremic syndrome
KW - Shiga toxin-producing Escherichia coli
KW - Renal replacement therapy
N2 - Diarrhea-associated hemolytic uremic syndrome is characterized by hemolytic anemia, thrombocytopenia, and acute kidney injury secondary to enteric infection, typically Shiga toxin-producing Escherichia coli. Shiga toxin 2 is able to activate alternative complement pathways; therefore, the aim of the study was to analyze C3 as a predictor of clinical courses in patients with diarrhea-associated hemolytic uremic syndrome. We hypothesized that the patients with increased complement activation at admission suffered from a more severe course. We retrospectively analyzed data of 33 pediatric patients between 1999 and 2015 in the Czech Republic. We tested the association of a C3 concentration with biochemical parameters and the clinical data reflecting the severity of the disease. We found significant correlation between the initial C3 and the duration of renal replacement therapy (r=-0.62, p=0.0001) and the initial glomerular filtration rate (r=0.36, p=0.026). Patients with C3<0.825g/L needed renal replacement therapy and also had significantly more renal complications (p=0.015).Conclusion: Based on our study, decreased C3 concentrations can be used as one of the risk factors that can help predict the need for acute dialysis and a more severe course of disease in children with diarrhea-associated hemolytic uremic syndrome.
ER -
KARNISOVA, Lucia, Ondrej HRADSKY, Kveta BLAHOVA, Filip FENCL, Zdeněk DOLEŽEL, Tomas ZAORAL and Jakub ZIEG. Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study. \textit{European journal of pediatrics}. New York: Springer, 2018, vol.~177, No~12, p.~1837-1844. ISSN~0340-6199. Available from: https://dx.doi.org/10.1007/s00431-018-3255-2.
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