SLANINA, Tomáš and Peter ŠEBEJ. Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2018, vol. 17, No 6, p. 692-710. ISSN 1474-905X. Available from: https://dx.doi.org/10.1039/c8pp00096d.
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Basic information
Original name Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window
Authors SLANINA, Tomáš (203 Czech Republic) and Peter ŠEBEJ (703 Slovakia, guarantor, belonging to the institution).
Edition PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, CAMBRIDGE, ROYAL SOC CHEMISTRY, 2018, 1474-905X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10403 Physical chemistry
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.408
RIV identification code RIV/00216224:14310/18:00104735
Organization unit Faculty of Science
Doi http://dx.doi.org/10.1039/c8pp00096d
UT WoS 000435358900001
Keywords in English PHOTOREMOVABLE PROTECTING GROUPS; METAL-CARBONYL-COMPLEXES; PROTEIN-KINASE PATHWAY; LIVING CELLS; NITRIC-OXIDE; AQUEOUS-SOLUTION; NIR LIGHT; IN-VIVO; STRUCTURAL-CHARACTERIZATION; XANTHENE-9-CARBOXYLIC ACID
Tags International impact, Reviewed
Changed by Changed by: Mgr. Michaela Hylsová, Ph.D., učo 211937. Changed: 30/11/2018 21:37.
Abstract
To date, most known molecules that release carbon monoxide by the action of light are based on carbonyl complexes of metals. However, they suffer from several disadvantages, so the focus of this perspective is on photoactivatable metal-free CO precursors. The development and design of these systems from the starting point of deep-UV-absorbing hydrophobic molecules and leading to hydrophilic biocompatible visible-light-absorbing CO-releasing molecules (photoCORMs) is described with mechanistic details for several structural motifs. The possibilities of this development are not exhausted and here we discuss the design of new biologically interesting candidates.
Links
CZ.02.1.01/0.0/0.0/16_013/0001761, interní kód MUName: RECETOX RI - OP VVV (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR, Priority axis 1: Strengthening capacities for high-quality research
LM2015051, research and development projectName: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)
Investor: Ministry of Education, Youth and Sports of the CR
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