Visible-light-activated photoCORMs: rational design of
CO-releasing organic molecules absorbing in the
tissue-transparent window

J 2018

Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window

SLANINA, Tomáš and Peter ŠEBEJ

Basic information

Original name

Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window

Authors

SLANINA, Tomáš (203 Czech Republic) and Peter ŠEBEJ (703 Slovakia, guarantor, belonging to the institution)

Edition

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, CAMBRIDGE, ROYAL SOC CHEMISTRY, 2018, 1474-905X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10403 Physical chemistry

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 2.408

RIV identification code

RIV/00216224:14310/18:00104735

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1039/c8pp00096d

UT WoS

000435358900001

Keywords in English

PHOTOREMOVABLE PROTECTING GROUPS; METAL-CARBONYL-COMPLEXES; PROTEIN-KINASE PATHWAY; LIVING CELLS; NITRIC-OXIDE; AQUEOUS-SOLUTION; NIR LIGHT; IN-VIVO; STRUCTURAL-CHARACTERIZATION; XANTHENE-9-CARBOXYLIC ACID

Abstract

V originále

To date, most known molecules that release carbon monoxide by the action of light are based on carbonyl complexes of metals. However, they suffer from several disadvantages, so the focus of this perspective is on photoactivatable metal-free CO precursors. The development and design of these systems from the starting point of deep-UV-absorbing hydrophobic molecules and leading to hydrophilic biocompatible visible-light-absorbing CO-releasing molecules (photoCORMs) is described with mechanistic details for several structural motifs. The possibilities of this development are not exhausted and here we discuss the design of new biologically interesting candidates.

Links

CZ.02.1.01/0.0/0.0/16_013/0001761, interní kód MU

Name: RECETOX RI - OP VVV (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, Priority axis 1: Strengthening capacities for high-quality research

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

SLANINA, Tomáš and Peter ŠEBEJ. Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2018, vol. 17, No 6, p. 692-710. ISSN 1474-905X. Available from: https://dx.doi.org/10.1039/c8pp00096d.

@article{1473623,
   author = {Slanina, Tomáš and Šebej, Peter},
   article_location = {CAMBRIDGE},
   article_number = {6},
   doi = {http://dx.doi.org/10.1039/c8pp00096d},
   keywords = {PHOTOREMOVABLE PROTECTING GROUPS; METAL-CARBONYL-COMPLEXES; PROTEIN-KINASE PATHWAY; LIVING CELLS; NITRIC-OXIDE; AQUEOUS-SOLUTION; NIR LIGHT; IN-VIVO; STRUCTURAL-CHARACTERIZATION; XANTHENE-9-CARBOXYLIC ACID},
   language = {eng},
   issn = {1474-905X},
   journal = {PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES},
   title = {Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window},
   url = {https://pubs.rsc.org/en/Content/ArticleLanding/2018/PP/C8PP00096D#!divAbstract},
   volume = {17},
   year = {2018}
}

TY  - JOUR
ID  - 1473623
AU  - Slanina, Tomáš - Šebej, Peter
PY  - 2018
TI  - Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window
JF  - PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
VL  - 17
IS  - 6
SP  - 692-710
EP  - 692-710
PB  - ROYAL SOC CHEMISTRY
SN  - 1474905X
KW  - PHOTOREMOVABLE PROTECTING GROUPS
KW  - METAL-CARBONYL-COMPLEXES
KW  - PROTEIN-KINASE PATHWAY
KW  - LIVING CELLS
KW  - NITRIC-OXIDE
KW  - AQUEOUS-SOLUTION
KW  - NIR LIGHT
KW  - IN-VIVO
KW  - STRUCTURAL-CHARACTERIZATION
KW  - XANTHENE-9-CARBOXYLIC ACID
UR  - https://pubs.rsc.org/en/Content/ArticleLanding/2018/PP/C8PP00096D#!divAbstract
L2  - https://pubs.rsc.org/en/Content/ArticleLanding/2018/PP/C8PP00096D#!divAbstract
N2  - To date, most known molecules that release carbon monoxide by the action of light are based on carbonyl complexes of metals. However, they suffer from several disadvantages, so the focus of this perspective is on photoactivatable metal-free CO precursors. The development and design of these systems from the starting point of deep-UV-absorbing hydrophobic molecules and leading to hydrophilic biocompatible visible-light-absorbing CO-releasing molecules (photoCORMs) is described with mechanistic details for several structural motifs. The possibilities of this development are not exhausted and here we discuss the design of new biologically interesting candidates.
ER  -

SLANINA, Tomáš and Peter ŠEBEJ. Visible-light-activated photoCORMs: rational design of CO-releasing organic molecules absorbing in the tissue-transparent window. \textit{PHOTOCHEMICAL \&{}amp; PHOTOBIOLOGICAL SCIENCES}. CAMBRIDGE: ROYAL SOC CHEMISTRY, 2018, vol.~17, No~6, p.~692-710. ISSN~1474-905X. Available from: https://dx.doi.org/10.1039/c8pp00096d.

Detailed Information on Publication Record