| JANTSCH, M.F., A. QUATTRONE, Mary Anne O'CONNELL, M. HELM, M. FRYE, M. MACIAS-GONZALES, M. OHMAN, S. AMERES, L. WILLEMS, F. FUKS, A. OULAS, Štěpánka VAŇÁČOVÁ, H. NIELSEN, C. BOUSQUET-ANTONELLI, Y. MOTORIN, J.Y. ROIGNANT, N. BALATSOS, A. DINNYES, P. BARANOV, V. KELLY, A. LAMM, G. RECHAVI, M. PELIZZOLA, J. LIEPINS, I.H. KHOLODNYUK, V. ZAMMIT, D. AYERS, F. DRABLOS, J.A. DAHL, J. BUJNICKI, C. JERONIMO, R. ALMEIDA, M. NEAGU, M. COSTACHE, J. BANKOVIC, B. BANOVIC, J. KYSELOVIC, L.M. VALOR, S. SELBERT, P. PIR, T. DEMIRCAN, V. COWLING, M. SCHAFER, W. ROSSMANITH, D. LAFONTAINE, A. DAVID, C. CARRE, F. LYKO, R. SCHAFFRATH, S. SCHWARTZ, A. VERDEL, A. KLUNGLAND, E. PURTA, G. TIMOTIJEVIC, F. CARDONA, A. DAVALOS, E. BALLANA, D. O CARROLL, J. ULE and R. FRAY. Positioning Europe for the EPITRANSCRIPTOMICS challenge. RNA BIOLOGY. PHILADELPHIA: TAYLOR & FRANCIS INC, 2018, vol. 15, No 6, p. 829-831. ISSN 1547-6286. Available from: https://dx.doi.org/10.1080/15476286.2018.1460996. |
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@article{1474618,
author = {Jantsch, M.F. and Quattrone, A. and O'Connell, Mary Anne and Helm, M. and Frye, M. and MaciasandGonzales, M. and Ohman, M. and Ameres, S. and Willems, L. and Fuks, F. and Oulas, A. and Vaňáčová, Štěpánka and Nielsen, H. and BousquetandAntonelli, C. and Motorin, Y. and Roignant, J.Y. and Balatsos, N. and Dinnyes, A. and Baranov, P. and Kelly, V. and Lamm, A. and Rechavi, G. and Pelizzola, M. and Liepins, J. and Kholodnyuk, I.H. and Zammit, V. and Ayers, D. and Drablos, F. and Dahl, J.A. and Bujnicki, J. and Jeronimo, C. and Almeida, R. and Neagu, M. and Costache, M. and Bankovic, J. and Banovic, B. and Kyselovic, J. and Valor, L.M. and Selbert, S. and Pir, P. and Demircan, T. and Cowling, V. and Schafer, M. and Rossmanith, W. and Lafontaine, D. and David, A. and Carre, C. and Lyko, F. and Schaffrath, R. and Schwartz, S. and Verdel, A. and Klungland, A. and Purta, E. and Timotijevic, G. and Cardona, F. and Davalos, A. and Ballana, E. and O Carroll, D. and Ule, J. and Fray, R.},
article_location = {PHILADELPHIA},
article_number = {6},
doi = {http://dx.doi.org/10.1080/15476286.2018.1460996},
keywords = {database of Modification; detection of RNA modification; epitranscriptomics; European funding; model systems},
language = {eng},
issn = {1547-6286},
journal = {RNA BIOLOGY},
title = {Positioning Europe for the EPITRANSCRIPTOMICS challenge},
url = {http://dx.doi.org/10.1080/15476286.2018.1460996},
volume = {15},
year = {2018}
}
TY - JOUR
ID - 1474618
AU - Jantsch, M.F. - Quattrone, A. - O'Connell, Mary Anne - Helm, M. - Frye, M. - Macias-Gonzales, M. - Ohman, M. - Ameres, S. - Willems, L. - Fuks, F. - Oulas, A. - Vaňáčová, Štěpánka - Nielsen, H. - Bousquet-Antonelli, C. - Motorin, Y. - Roignant, J.Y. - Balatsos, N. - Dinnyes, A. - Baranov, P. - Kelly, V. - Lamm, A. - Rechavi, G. - Pelizzola, M. - Liepins, J. - Kholodnyuk, I.H. - Zammit, V. - Ayers, D. - Drablos, F. - Dahl, J.A. - Bujnicki, J. - Jeronimo, C. - Almeida, R. - Neagu, M. - Costache, M. - Bankovic, J. - Banovic, B. - Kyselovic, J. - Valor, L.M. - Selbert, S. - Pir, P. - Demircan, T. - Cowling, V. - Schafer, M. - Rossmanith, W. - Lafontaine, D. - David, A. - Carre, C. - Lyko, F. - Schaffrath, R. - Schwartz, S. - Verdel, A. - Klungland, A. - Purta, E. - Timotijevic, G. - Cardona, F. - Davalos, A. - Ballana, E. - O Carroll, D. - Ule, J. - Fray, R.
PY - 2018
TI - Positioning Europe for the EPITRANSCRIPTOMICS challenge
JF - RNA BIOLOGY
VL - 15
IS - 6
SP - 829-831
EP - 829-831
PB - TAYLOR & FRANCIS INC
SN - 15476286
KW - database of Modification
KW - detection of RNA modification
KW - epitranscriptomics
KW - European funding
KW - model systems
UR - http://dx.doi.org/10.1080/15476286.2018.1460996
L2 - http://dx.doi.org/10.1080/15476286.2018.1460996
N2 - The genetic alphabet consists of the four letters: C, A, G, and T in DNA and C,A,G, and U in RNA. Triplets of these four letters jointly encode 20 different amino acids out of which proteins of all organisms are built. This system is universal and is found in all kingdoms of life. However, bases in DNA and RNA can be chemically modified. In DNA, around 10 different modifications are known, and those have been studied intensively over the past 20years. Scientific studies on DNA modifications and proteins that recognize them gave rise to the large field of epigenetic and epigenomic research. The outcome of this intense research field is the discovery that development, ageing, and stem-cell dependent regeneration but also several diseases including cancer are largely controlled by the epigenetic state of cells. Consequently, this research has already led to the first FDA approved drugs that exploit the gained knowledge to combat disease. In recent years, the similar to 150 modifications found in RNA have come to the focus of intense research. Here we provide a perspective on necessary and expected developments in the fast expanding area of RNA modifications, termed epitranscriptomics.
ER -
JANTSCH, M.F., A. QUATTRONE, Mary Anne O'CONNELL, M. HELM, M. FRYE, M. MACIAS-GONZALES, M. OHMAN, S. AMERES, L. WILLEMS, F. FUKS, A. OULAS, Štěpánka VAŇÁČOVÁ, H. NIELSEN, C. BOUSQUET-ANTONELLI, Y. MOTORIN, J.Y. ROIGNANT, N. BALATSOS, A. DINNYES, P. BARANOV, V. KELLY, A. LAMM, G. RECHAVI, M. PELIZZOLA, J. LIEPINS, I.H. KHOLODNYUK, V. ZAMMIT, D. AYERS, F. DRABLOS, J.A. DAHL, J. BUJNICKI, C. JERONIMO, R. ALMEIDA, M. NEAGU, M. COSTACHE, J. BANKOVIC, B. BANOVIC, J. KYSELOVIC, L.M. VALOR, S. SELBERT, P. PIR, T. DEMIRCAN, V. COWLING, M. SCHAFER, W. ROSSMANITH, D. LAFONTAINE, A. DAVID, C. CARRE, F. LYKO, R. SCHAFFRATH, S. SCHWARTZ, A. VERDEL, A. KLUNGLAND, E. PURTA, G. TIMOTIJEVIC, F. CARDONA, A. DAVALOS, E. BALLANA, D. O CARROLL, J. ULE and R. FRAY. Positioning Europe for the EPITRANSCRIPTOMICS challenge. \textit{RNA BIOLOGY}. PHILADELPHIA: TAYLOR \&{}amp; FRANCIS INC, 2018, vol.~15, No~6, p.~829-831. ISSN~1547-6286. Available from: https://dx.doi.org/10.1080/15476286.2018.1460996.
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