HOFER, M., Z. HOFEROVA, A. GRUZDEV, Ladislav DUŠEK and M. FALK. Impaired Post-Irradiation Survival of Cyclooxygenase-2-Deficient Mice. Physiological research. Praha: Fyziologický ústav AV ČR, 2018, vol. 67, No 5, p. 809-812. ISSN 0862-8408. |
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@article{1474681, author = {Hofer, M. and Hoferova, Z. and Gruzdev, A. and Dušek, Ladislav and Falk, M.}, article_location = {Praha}, article_number = {5}, keywords = {Cyclooxygenase-2; COX-2 knock-out mice; Ionizing radiation; Post-irradiation survival; Post-irradiation inflammation}, language = {eng}, issn = {0862-8408}, journal = {Physiological research}, title = {Impaired Post-Irradiation Survival of Cyclooxygenase-2-Deficient Mice}, volume = {67}, year = {2018} }
TY - JOUR ID - 1474681 AU - Hofer, M. - Hoferova, Z. - Gruzdev, A. - Dušek, Ladislav - Falk, M. PY - 2018 TI - Impaired Post-Irradiation Survival of Cyclooxygenase-2-Deficient Mice JF - Physiological research VL - 67 IS - 5 SP - 809-812 EP - 809-812 PB - Fyziologický ústav AV ČR SN - 08628408 KW - Cyclooxygenase-2 KW - COX-2 knock-out mice KW - Ionizing radiation KW - Post-irradiation survival KW - Post-irradiation inflammation N2 - We investigated and evaluated post-irradiation survival in cyclooxygenase-2-deficient (COX-2 KO) mice. Thirty-day survival following exposure of COX-2 KO mice to a lethal dose of 8.5 Gy of gamma-rays was observed to be statistically significantly lower in both males and females, as well as when the sexes were merged, in comparisons with their wild-type counterparts. These findings were related to the previous observations concerning the detrimental influence of the COX-2 genetic disruption on hematopoiesis in sublethally irradiated mice. Deteriorated postirradiation survival of COX-2 KO mice confirmed the previously anticipated conclusion regarding negative influence of the antiinflammatory action of COX-2 deficiency under the conditions of exposure of the animals to ionizing radiation. ER -
HOFER, M., Z. HOFEROVA, A. GRUZDEV, Ladislav DUŠEK and M. FALK. Impaired Post-Irradiation Survival of Cyclooxygenase-2-Deficient Mice. \textit{Physiological research}. Praha: Fyziologický ústav AV ČR, 2018, vol.~67, No~5, p.~809-812. ISSN~0862-8408.
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