| HOFER, M., Z. HOFEROVA, A. GRUZDEV, Ladislav DUŠEK and M. FALK. Impaired Post-Irradiation Survival of Cyclooxygenase-2-Deficient Mice. Physiological research. Praha: Fyziologický ústav AV ČR, 2018, vol. 67, No 5, p. 809-812. ISSN 0862-8408. |
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@article{1474681,
author = {Hofer, M. and Hoferova, Z. and Gruzdev, A. and Dušek, Ladislav and Falk, M.},
article_location = {Praha},
article_number = {5},
keywords = {Cyclooxygenase-2; COX-2 knock-out mice; Ionizing radiation; Post-irradiation survival; Post-irradiation inflammation},
language = {eng},
issn = {0862-8408},
journal = {Physiological research},
title = {Impaired Post-Irradiation Survival of Cyclooxygenase-2-Deficient Mice},
volume = {67},
year = {2018}
}
TY - JOUR
ID - 1474681
AU - Hofer, M. - Hoferova, Z. - Gruzdev, A. - Dušek, Ladislav - Falk, M.
PY - 2018
TI - Impaired Post-Irradiation Survival of Cyclooxygenase-2-Deficient Mice
JF - Physiological research
VL - 67
IS - 5
SP - 809-812
EP - 809-812
PB - Fyziologický ústav AV ČR
SN - 08628408
KW - Cyclooxygenase-2
KW - COX-2 knock-out mice
KW - Ionizing radiation
KW - Post-irradiation survival
KW - Post-irradiation inflammation
N2 - We investigated and evaluated post-irradiation survival in cyclooxygenase-2-deficient (COX-2 KO) mice. Thirty-day survival following exposure of COX-2 KO mice to a lethal dose of 8.5 Gy of gamma-rays was observed to be statistically significantly lower in both males and females, as well as when the sexes were merged, in comparisons with their wild-type counterparts. These findings were related to the previous observations concerning the detrimental influence of the COX-2 genetic disruption on hematopoiesis in sublethally irradiated mice. Deteriorated postirradiation survival of COX-2 KO mice confirmed the previously anticipated conclusion regarding negative influence of the antiinflammatory action of COX-2 deficiency under the conditions of exposure of the animals to ionizing radiation.
ER -
HOFER, M., Z. HOFEROVA, A. GRUZDEV, Ladislav DUŠEK and M. FALK. Impaired Post-Irradiation Survival of Cyclooxygenase-2-Deficient Mice. \textit{Physiological research}. Praha: Fyziologický ústav AV ČR, 2018, vol.~67, No~5, p.~809-812. ISSN~0862-8408.
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