Detailed Information on Publication Record
2018
Impaired Post-Irradiation Survival of Cyclooxygenase-2-Deficient Mice
HOFER, M., Z. HOFEROVA, A. GRUZDEV, Ladislav DUŠEK, M. FALK et. al.Basic information
Original name
Impaired Post-Irradiation Survival of Cyclooxygenase-2-Deficient Mice
Authors
HOFER, M. (203 Czech Republic, guarantor), Z. HOFEROVA (203 Czech Republic), A. GRUZDEV (840 United States of America), Ladislav DUŠEK (203 Czech Republic, belonging to the institution) and M. FALK (203 Czech Republic)
Edition
Physiological research, Praha, Fyziologický ústav AV ČR, 2018, 0862-8408
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30105 Physiology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.701
RIV identification code
RIV/00216224:14110/18:00101397
Organization unit
Faculty of Medicine
UT WoS
000449861300016
Keywords in English
Cyclooxygenase-2; COX-2 knock-out mice; Ionizing radiation; Post-irradiation survival; Post-irradiation inflammation
Tags
International impact, Reviewed
Změněno: 10/2/2019 14:41, Soňa Böhmová
Abstract
V originále
We investigated and evaluated post-irradiation survival in cyclooxygenase-2-deficient (COX-2 KO) mice. Thirty-day survival following exposure of COX-2 KO mice to a lethal dose of 8.5 Gy of gamma-rays was observed to be statistically significantly lower in both males and females, as well as when the sexes were merged, in comparisons with their wild-type counterparts. These findings were related to the previous observations concerning the detrimental influence of the COX-2 genetic disruption on hematopoiesis in sublethally irradiated mice. Deteriorated postirradiation survival of COX-2 KO mice confirmed the previously anticipated conclusion regarding negative influence of the antiinflammatory action of COX-2 deficiency under the conditions of exposure of the animals to ionizing radiation.
Links
| GBP302/12/G157, research and development project |
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