Detailed Information on Publication Record
2018
Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study
PILER, Pavel, Jan ŠVANCARA, Lubomír KUKLA and Hynek PIKHARTBasic information
Original name
Role of combined prenatal and postnatal paracetamol exposure on asthma development: the Czech ELSPAC study
Authors
PILER, Pavel (203 Czech Republic, belonging to the institution), Jan ŠVANCARA (203 Czech Republic, belonging to the institution), Lubomír KUKLA (203 Czech Republic, belonging to the institution) and Hynek PIKHART (203 Czech Republic, guarantor, belonging to the institution)
Edition
Journal of Epidemiology and Community Health, LONDON, BMJ PUBLISHING GROUP, 2018, 0143-005X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30304 Public and environmental health
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 3.872
RIV identification code
RIV/00216224:14310/18:00104779
Organization unit
Faculty of Science
UT WoS
000429428000014
Keywords in English
asthma; drug safety; cohort studies; epidemiology
Tags
International impact, Reviewed
Změněno: 9/1/2019 19:12, Mgr. Michaela Hylsová, Ph.D.
Abstract
V originále
Background Prenatal and postnatal paracetamol exposure has been previously associated with asthma development in childhood in Western populations. We explore the association between prenatal and postnatal paracetamol exposure and asthma development in a Central European sample of Czech children, suggesting possible additive effect of the both exposures. Furthermore, since aspirin had been used more widely during study data collection in Central Europe, we also compared asthma development for those exposed to paracetamol and aspirin. Methods We used data from 3329 children born in the 1990s as members of the prospective Czech European Longitudinal Study of Pregnancy and Childhood. Data about prenatal and postnatal paracetamol and aspirin exposure, and potential covariates were obtained from questionnaires completed by mothers. Data about incident asthma were obtained from paediatrician health records. Results 60.9% of children received paracetamol only postnatally, 1.5% only prenatally and 4.9% of children were exposed both during pregnancy and infancy. Prevalence of asthma in following population was 5% at 11 years. Being exposed to paracetamol both in prenatal and postnatal period was associated with asthma development (unadjusted OR 1.98, 95%CI 1.02 to 3.87). Being exposed only in the postnatal period was also significantly associated with increased risk of asthma. No association between prenatal exposure only and outcome was found. A higher but non-significant risk of asthma was observed for those whose mothers used paracetamol during pregnancy compared with those who used aspirin. Conclusions The main findings of this prospective birth cohort study add to previous observations linking prenatal and early postnatal paracetamol exposure to asthma development. However, the magnitude of effect is relatively modest, and therefore, we recommend paracetamol to remain the analgesic and antipyretic of choice throughout pregnancy and early childhood.
Links
| CZ.02.1.01/0.0/0.0/16_013/0001761, interní kód MU |
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| EF15_003/0000469, research and development project |
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| LM2015051, research and development project |
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