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@article{1475638,
author = {Králová, Tereza and Albrecht, Tomáš and Bryja, Josef and Hořák, D. and Johnsen, A. and Lifjeld, J.T. and Novotny, M. and Sedlacek, O. and Velova, H. and Vinkler, Michal},
article_number = {13},
doi = {http://dx.doi.org/10.1111/mec.14724},
keywords = {functional evolution; host-pathogen interaction; surface charge distribution; TLR4 molecular phenotype; Toll-like receptors},
language = {eng},
issn = {0962-1083},
journal = {Molecular Ecology},
title = {Signatures of diversifying selection and convergence acting on passerine Toll-like receptor 4 in an evolutionary context},
url = {http://dx.doi.org/10.1111/mec.14724},
volume = {27},
year = {2018}
}
TY - JOUR
ID - 1475638
AU - Králová, Tereza - Albrecht, Tomáš - Bryja, Josef - Hořák, D. - Johnsen, A. - Lifjeld, J.T. - Novotny, M. - Sedlacek, O. - Velova, H. - Vinkler, Michal
PY - 2018
TI - Signatures of diversifying selection and convergence acting on passerine Toll-like receptor 4 in an evolutionary context
JF - Molecular Ecology
VL - 27
IS - 13
SP - 2871-2883
EP - 2871-2883
PB - Blackwell Publishing Ltd.
SN - 09621083
KW - functional evolution
KW - host-pathogen interaction
KW - surface charge distribution
KW - TLR4 molecular phenotype
KW - Toll-like receptors
UR - http://dx.doi.org/10.1111/mec.14724
N2 - Positive selection acting on Toll-like receptors (TLRs) has been recently investigated to reveal evolutionary mechanisms of host-pathogen molecular co-adaptation. Much of this research, however, has focused mainly on the identification of sites predicted to be under positive selection, bringing little insight into the functional differences and similarities among species and a limited understanding of convergent evolution in the innate immune molecules. In this study, we provide evidence of phenotypic variability in the avian TLR4 ligand-binding region (LBR), the direct interface between host and pathogen molecular structures. We show that 55 passerine species vary substantially in the distribution of electrostatic potential on the surface of the receptor, and based on these distinct patterns, we identified four species clusters. Seven of the 34 evolutionarily nonconservative and positively selected residues correspond topologically to sites previously identified as being important for lipopolysaccharide, lipid IVa or MD-2 binding. Five of these positions codetermine the identity of the charge clusters. Groups of species that host-related communities of pathogens were predicted to cluster based on their TLR4 LBR charge. Despite some evidence for convergence among taxa, there were no clear associations between the TLR4 LBR charge distribution and any of the general ecological characteristics compared (migration, latitudinal distribution and diet). Closely related species, however, mostly belonged to the same surface charge cluster indicating that phylogenetic constraints are key determinants shaping TLR4 adaptive evolution. Our results suggest that host innate immune evolution is consistent with Fahrenholz's rule on the cospeciation of hosts and their parasites.
ER -
KRÁLOVÁ, Tereza, Tomáš ALBRECHT, Josef BRYJA, D. HOŘÁK, A. JOHNSEN, J.T. LIFJELD, M. NOVOTNY, O. SEDLACEK, H. VELOVA and Michal VINKLER. Signatures of diversifying selection and convergence acting on passerine Toll-like receptor 4 in an evolutionary context. \textit{Molecular Ecology}. Blackwell Publishing Ltd., 2018, vol.~27, No~13, p.~2871-2883. ISSN~0962-1083. Available from: https://dx.doi.org/10.1111/mec.14724.
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