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@inbook{1475736,
author = {Červený, Jan and Šalagovič, Jakub and Muzika, František and Šafránek, David and Schreiber, Igor},
address = {Neuveden},
booktitle = {Cyanobacteria: From Basic Science to Applications},
doi = {http://dx.doi.org/10.1016/B978-0-12-814667-5.00009-X},
edition = {1st ed.},
editor = {Mishra, A. K.; Tiwari, D.; Rai, A. N.},
keywords = {Computational modeling; Bioreactor; Formal methods; Industry 4.0; Microalgae; Network analysis; Optimization; Process control},
howpublished = {elektronická verze "online"},
language = {eng},
location = {Neuveden},
isbn = {978-0-12-814667-5},
pages = {193-206},
publisher = {Academic Press},
title = {Influence of circadian clocks on optimal regime of central C-N metabolism of cyanobacteria},
url = {https://doi.org/10.1016/B978-0-12-814667-5.00009-X},
year = {2018}
}
TY - CHAP
ID - 1475736
AU - Červený, Jan - Šalagovič, Jakub - Muzika, František - Šafránek, David - Schreiber, Igor
PY - 2018
TI - Influence of circadian clocks on optimal regime of central C-N metabolism of cyanobacteria
VL - Neuveden
PB - Academic Press
CY - Neuveden
SN - 9780128146675
KW - Computational modeling
KW - Bioreactor
KW - Formal methods
KW - Industry 4.0
KW - Microalgae
KW - Network analysis
KW - Optimization
KW - Process control
UR - https://doi.org/10.1016/B978-0-12-814667-5.00009-X
N2 - Mechanistic aspects of cyanobacteria clock and metabolism have been analyzed in considerable detail during recent decades, but only limited knowledge is available about particular link(s) between the clock and controlled metabolic processes. We describe a case study where we couple a mechanistic model of a circadian oscillator with a model of central carbon-nitrogen metabolism and apply formal methods based on temporal logic and bifurcation analysis to examine response of the metabolic part of the combined model to the autonomous clock oscillations. The analysis identified a set of parametric groups that, when applied to the in silico system, lead either to an optimal configuration of metabolic pathways for most efficient rhythmic function of the metabolism or to (oscillatory) system death. Under controlled conditions in monitored environments, such as cultivation in photobioreactors, the knowledge can be used for optimal regulation of production capacity that would reflect dynamic constraints of real world systems.
ER -
ČERVENÝ, Jan, Jakub ŠALAGOVIČ, František MUZIKA, David ŠAFRÁNEK a Igor SCHREIBER. Influence of circadian clocks on optimal regime of central C-N metabolism of cyanobacteria. In Mishra, A. K.; Tiwari, D.; Rai, A. N. \textit{Cyanobacteria: From Basic Science to Applications}. 1st ed. Neuveden: Academic Press. s.~193-206. ISBN~978-0-12-814667-5. doi:10.1016/B978-0-12-814667-5.00009-X. 2018.
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