| KAUROV, Losif, Marie VANCOVÁ, Bernd SCHIMANSKI, Lawrence Rudy CADENA, Jiří HELLER, Tomáš BÍLÝ, David POTĚŠIL, Caludia EICHENBERGER, Hannah BRUCE, Silke OELJAKLAUS, Bettina WARSCHEID, Zbyněk ZDRÁHAL, Andre SCHNEIDER, Julius LUKEŠ a Hassan HASHIMI. The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein Import. Current Biology. Elsevier Science, 2018, roč. 28, č. 21, s. 3393-3407, 20 s. ISSN 0960-9822. Dostupné z: https://dx.doi.org/10.1016/j.cub.2018.09.008. |
Další formáty:
BibTeX
LaTeX
RIS
@article{1475797,
author = {Kaurov, Losif and Vancová, Marie and Schimanski, Bernd and Cadena, Lawrence Rudy and Heller, Jiří and Bílý, Tomáš and Potěšil, David and Eichenberger, Caludia and Bruce, Hannah and Oeljaklaus, Silke and Warscheid, Bettina and Zdráhal, Zbyněk and Schneider, Andre and Lukeš, Julius and Hashimi, Hassan},
article_number = {21},
doi = {http://dx.doi.org/10.1016/j.cub.2018.09.008},
keywords = {CONTACT SITE; ORGANIZING SYSTEM; INTERMEMBRANE SPACE; INNER MEMBRANE; OUTER-MEMBRANE; MIA PATHWAY; BRUCEI; ORGANIZATION; ARCHITECTURE; BIOGENESIS},
language = {eng},
issn = {0960-9822},
journal = {Current Biology},
title = {The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein Import},
volume = {28},
year = {2018}
}
TY - JOUR
ID - 1475797
AU - Kaurov, Losif - Vancová, Marie - Schimanski, Bernd - Cadena, Lawrence Rudy - Heller, Jiří - Bílý, Tomáš - Potěšil, David - Eichenberger, Caludia - Bruce, Hannah - Oeljaklaus, Silke - Warscheid, Bettina - Zdráhal, Zbyněk - Schneider, Andre - Lukeš, Julius - Hashimi, Hassan
PY - 2018
TI - The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein Import
JF - Current Biology
VL - 28
IS - 21
SP - 3393-3407
EP - 3393-3407
PB - Elsevier Science
SN - 09609822
KW - CONTACT SITE
KW - ORGANIZING SYSTEM
KW - INTERMEMBRANE SPACE
KW - INNER MEMBRANE
KW - OUTER-MEMBRANE
KW - MIA PATHWAY
KW - BRUCEI
KW - ORGANIZATION
KW - ARCHITECTURE
KW - BIOGENESIS
N2 - The mitochondrial contact site and cristae organization system (MICOS) is a multiprotein complex responsible for cristae formation. Even though cristae are found in all mitochondria capable of oxidative phosphorylation, only Mic10 and Mic60 appear to be conserved throughout eukaryotes. The remaining 4 or 5 known MICOS subunits are specific to the supergroup Opisthokonta, which includes yeast and mammals that are the only organisms in which this complex has been analyzed experimentally. We have isolated the MICOS from Trypanosoma brucei, a member of the supergroup Excavata that is profoundly diverged from opisthokonts. We show that it is required for the maintenance of the unique discoidal cristae that typify excavates, such as euglenids and kinetoplastids, the latter of which include trypanosomes. The trypanosome MICOS consists of 9 subunits, most of which are essential for normal growth. Unlike in opisthokonts, it contains two distinct Mic10 orthologs and an unconventional putative Mic60 that lacks a mitofilin domain. Interestingly, one of the essential trypanosomatid-specific MICOS subunits called TbMic20 is a thioredoxin-like protein that appears to be involved in import of intermembrane space proteins, including respiratory chain complex assembly factors. This result points to trypanosome MICOS coordinating cristae shaping and population of its membrane with proteins involved in respiration, the latter via the catalytic activity of TbMic20. Thus, trypanosome MICOS allows us to define which of its features are conserved in all eukaryotes and decipher those that represent lineage-specific adaptations.
ER -
KAUROV, Losif, Marie VANCOVÁ, Bernd SCHIMANSKI, Lawrence Rudy CADENA, Jiří HELLER, Tomáš BÍLÝ, David POTĚŠIL, Caludia EICHENBERGER, Hannah BRUCE, Silke OELJAKLAUS, Bettina WARSCHEID, Zbyněk ZDRÁHAL, Andre SCHNEIDER, Julius LUKEŠ a Hassan HASHIMI. The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein Import. \textit{Current Biology}. Elsevier Science, 2018, roč.~28, č.~21, s.~3393-3407, 20 s. ISSN~0960-9822. Dostupné z: https://dx.doi.org/10.1016/j.cub.2018.09.008.
|
