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@article{1477967,
author = {Depret, F. and Boutin, L. and Jarkovský, Jiří and Chaussard, M. and Soussi, S. and Bataille, A. and Oueslati, H. and Moreno, N. and Tymowski, C. de and Pařenica, Jiří and Benešová, Klára and Vauchel, T. and Ferry, A. and Benyamina, M. and Cupaciu, A. and Coutrot, M. and Garnier, J.P. and Serror, K. and Chaouat, M. and Mebazaa, A. and Legrand, M.},
article_location = {OXFORD},
article_number = {8},
doi = {http://dx.doi.org/10.1016/j.burns.2018.08.007},
keywords = {Plasmatic Neutrophil Gelatinase-Associated Lipocain; Acute kidney injury; Burn patients; Major adverse kidney event},
language = {eng},
issn = {0305-4179},
journal = {Burns},
title = {Prediction of major adverse kidney events in critically ill burn patients},
url = {https://www.sciencedirect.com/science/article/pii/S0305417918306922?via%3Dihub},
volume = {44},
year = {2018}
}
TY - JOUR
ID - 1477967
AU - Depret, F. - Boutin, L. - Jarkovský, Jiří - Chaussard, M. - Soussi, S. - Bataille, A. - Oueslati, H. - Moreno, N. - Tymowski, C. de - Pařenica, Jiří - Benešová, Klára - Vauchel, T. - Ferry, A. - Benyamina, M. - Cupaciu, A. - Coutrot, M. - Garnier, J.P. - Serror, K. - Chaouat, M. - Mebazaa, A. - Legrand, M.
PY - 2018
TI - Prediction of major adverse kidney events in critically ill burn patients
JF - Burns
VL - 44
IS - 8
SP - 1887-1894
EP - 1887-1894
PB - ELSEVIER SCI LTD
SN - 03054179
KW - Plasmatic Neutrophil Gelatinase-Associated Lipocain
KW - Acute kidney injury
KW - Burn patients
KW - Major adverse kidney event
UR - https://www.sciencedirect.com/science/article/pii/S0305417918306922?via%3Dihub
N2 - Objective: We aimed at assessing the predictive value of plasmatic Neutrophil Gelatinase Associated Lipocalin (pNGAL) at admission and severity scores to predict major adverse kidney events (MAKE, defined as death and/or need for renal replacement therapy (RRT) and/or non-renal recovery at day 90) in critically ill burn patients. Material and methods: Single-center cohort study in a burn critical care unit in a tertiary center, including all consecutive severely burn patients (total burned body surface >20%) from January 2012 until January 2015 with a pNGAL dosage at admission. Reclassification of patients was assessed by Integrated Discrimination Improvement (IDI). Measurements and results: 87 patients were included. Mean age was 47.7 (IQ 25-75: 33.4-65.2) years; total burn body surface area was 40 (IQ 25-75: 30-55) % and ICU mortality 36%. 39(44.8%) patients presented a MAKE, 32(88.9%) patients died at day 90. pNGAL was higher in the MAKE group (423 [IQ25-75: 327-518] pg/mL vs 184 [IQ25-75: 147-220] pg/mL, p<0.001). In multivariate analysis, pNGAL and abbreviated burn severity index (ABSI) remained associated with MAKE (OR 1.005 [CI 95% 1.0005-1.009], p=0.03 and OR 1.682 [CI95%1.038-2.726], p=0.035 respectively). Adding pNGAL to abbreviated burn severity index, simplified organ failure assessment and the simplified acute physiology score 2 did outperform clinical scores for the prediction of MAKE and AKI and for most severe forms of AKI and allowed a statistically significant reclassification of patients compared to ABSI for MAKE, RRT, AKI at Day 7 and AKI during hospitalization with a number of patients needed to screen to detect one extra episode of MAKE was 44, 13 for severe AKI and 15 for AKI. Conclusions: pNGAL at admission is associated with the risk of MAKE in this population, and outperform severity scores when associated. Interventional studies are now needed to assess if impact of biomarkers-guided strategies would improve outcome. (C) 2018 Elsevier Ltd and ISBI. All rights reserved.
ER -
DEPRET, F., L. BOUTIN, Jiří JARKOVSKÝ, M. CHAUSSARD, S. SOUSSI, A. BATAILLE, H. OUESLATI, N. MORENO, C. de TYMOWSKI, Jiří PAŘENICA, Klára BENEŠOVÁ, T. VAUCHEL, A. FERRY, M. BENYAMINA, A. CUPACIU, M. COUTROT, J.P. GARNIER, K. SERROR, M. CHAOUAT, A. MEBAZAA and M. LEGRAND. Prediction of major adverse kidney events in critically ill burn patients. \textit{Burns}. OXFORD: ELSEVIER SCI LTD, 2018, vol.~44, No~8, p.~1887-1894. ISSN~0305-4179. Available from: https://dx.doi.org/10.1016/j.burns.2018.08.007.
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