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@article{1479521,
author = {Zigáčková, Dagmar and Vaňáčová, Štěpánka},
article_location = {LONDON},
article_number = {1762},
doi = {http://dx.doi.org/10.1098/rstb.2018.0171},
keywords = {RNA uridylation; tutase; RNA modification; RNA surveillance; RNA processing; RNA degradation},
language = {eng},
issn = {0962-8436},
journal = {PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES},
title = {The role of 3 ' end uridylation in RNA metabolism and cellular physiology},
url = {https://royalsocietypublishing.org/doi/10.1098/rstb.2018.0171},
volume = {373},
year = {2018}
}
TY - JOUR
ID - 1479521
AU - Zigáčková, Dagmar - Vaňáčová, Štěpánka
PY - 2018
TI - The role of 3 ' end uridylation in RNA metabolism and cellular physiology
JF - PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
VL - 373
IS - 1762
SP - 20180171
EP - 20180171
PB - ROYAL SOC
SN - 09628436
KW - RNA uridylation
KW - tutase
KW - RNA modification
KW - RNA surveillance
KW - RNA processing
KW - RNA degradation
UR - https://royalsocietypublishing.org/doi/10.1098/rstb.2018.0171
N2 - Most eukaryotic RNAs are posttranscriptionally modified. The majority of modifications promote RNA maturation, others may regulate function and stability. The 3' terminal non-templated oligouridylation is a widespread modification affecting many cellular RNAs at some stage of their life cycle. It has diverse roles in RNA metabolism. The most prevalent is the regulation of stability and quality control. On the cellular and organismal level, it plays a critical role in a number of pathways, such as cell cycle regulation, cell death, development or viral infection. Defects in uridylation have been linked to several diseases. This review summarizes the current knowledge about the role of the 3' terminal oligo(U)-tailing in biology of various RNAs in eukaryotes and describes key factors involved in these pathways. This article is part of the theme issue '5' and 3' modifications controlling RNA degradation'.
ER -
ZIGÁČKOVÁ, Dagmar and Štěpánka VAŇÁČOVÁ. The role of 3 ' end uridylation in RNA metabolism and cellular physiology. \textit{PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES}. LONDON: ROYAL SOC, 2018, vol.~373, No~1762, p.~20180171-20180184. ISSN~0962-8436. Available from: https://dx.doi.org/10.1098/rstb.2018.0171.
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