RNA methylation in nuclear pre-mRNA processing

COVELO MOLARES, Helena, Marek BARTOŠOVIČ and Štěpánka VAŇÁČOVÁ. RNA methylation in nuclear pre-mRNA processing. Wiley Interdisciplinary Reviews: RNA. Hoboken, USA: WILEY-BLACKWELL, 2018, vol. 9, No 6, p. 1489-1505. ISSN 1757-7004. Available from: https://dx.doi.org/10.1002/wrna.1489.

Basic information

• Original name: RNA methylation in nuclear pre-mRNA processing
• Authors: COVELO MOLARES, Helena (724 Spain, belonging to the institution), Marek BARTOŠOVIČ (703 Slovakia, belonging to the institution) and Štěpánka VAŇÁČOVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Wiley Interdisciplinary Reviews: RNA, Hoboken, USA, WILEY-BLACKWELL, 2018, 1757-7004.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10601 Cell biology
• Country of publisher: United States of America
• Confidentiality degree: is not subject to a state or trade secret
• WWW: URL
• Impact factor: Impact factor: 4.928
• RIV identification code: RIV/00216224:14740/18:00101444
• Organization unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1002/wrna.1489
• UT WoS: 000447167100001
• Keywords in English: RNA demethylase; RNA methylase; RNA processing
• Tags: rivok
• Tags: International impact, Reviewed

Abstract

Eukaryotic RNA can carry more than 100 different types of chemical modifications. Early studies have been focused on modifications of highly abundant RNA, such as ribosomal RNA and transfer RNA, but recent technical advances have made it possible to also study messenger RNA (mRNA). Subsequently, mRNA modifications, namely methylation, have emerged as key players in eukaryotic gene expression regulation. The most abundant and widely studied internal mRNA modification is N-6-methyladenosine (m(6)A), but the list of mRNA chemical modifications continues to grow as fast as interest in this field. Over the past decade, transcriptome-wide studies combined with advanced biochemistry and the discovery of methylation writers, readers, and erasers revealed roles for mRNA methylation in the regulation of nearly every aspect of the mRNA life cycle and in diverse cellular, developmental, and disease processes. Although large parts of mRNA function are linked to its cytoplasmic stability and regulation of its translation, a number of studies have begun to provide evidence for methylation-regulated nuclear processes. In this review, we summarize the recent advances in RNA methylation research and highlight how these new findings have contributed to our understanding of methylation-dependent RNA processing in the nucleus. This article is categorized under: RNA Processing > RNA Editing and Modification RNA Processing > Splicing Regulation/Alternative Splicing RNA Interactions with Proteins and Other Molecules > Protein-RNA Interactions: Functional Implications

Links

• GAP305/11/1095, research and development project: Name: Funkční a biochemická charakterizace proteinu Dis3L2, třetího lidského homologu hlavní kvasinkové exosomové nukleázy Dis3p

Investor: Czech Science Foundation, Functional and biochemical characterization of Dis3L2, the third mammalian homolog of the key yeast exosome nuclease Dis3p

• GA14-25884S, research and development project: Name: Charakterizace substrátového repertoáru RNA lidské demetylázy FTO

Investor: Czech Science Foundation

• LQ1601, research and development project: Name: CEITEC 2020 (Acronym: CEITEC2020)

Investor: Ministry of Education, Youth and Sports of the CR

• 084316/Z/07/Z, interní kód MU: Name: Polyadenylation and mechanisms of nuclear RNA quality control

Investor: Wellcome Trust, Polyadenylation and mechanisms of nuclear RNA quality control