Hematological Findings in Non-Treated and gamma-Irradiated Mice
Deficient for MIC-1/GDF15

J 2018

Hematological Findings in Non-Treated and gamma-Irradiated Mice Deficient for MIC-1/GDF15

HOFER, M., Z. HOFEROVA, Ján REMŠÍK, M. NOVAKOVA, J. PROCHAZKOVA et. al.

Basic information

Original name

Hematological Findings in Non-Treated and gamma-Irradiated Mice Deficient for MIC-1/GDF15

Authors

HOFER, M. (203 Czech Republic, guarantor), Z. HOFEROVA (203 Czech Republic), Ján REMŠÍK (703 Slovakia, belonging to the institution), M. NOVAKOVA (203 Czech Republic), J. PROCHAZKOVA (203 Czech Republic), R. FEDR (203 Czech Republic), J. KOHOUTEK (203 Czech Republic), Ladislav DUŠEK (203 Czech Republic, belonging to the institution), Aleš HAMPL (203 Czech Republic, belonging to the institution) and K. SOUČEK (203 Czech Republic)

Edition

Physiological research, Praha, Fyziologický ústav AV ČR, 2018, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.701

RIV identification code

RIV/00216224:14110/18:00101446

Organization unit

Faculty of Medicine

UT WoS

000442016100011

Keywords in English

GDF15 knockout mice; Hematopoiesis; Ionizing radiation; Stress-induced cytokine

Abstract

V originále

Several members of the TGF-beta family are known to effectively regulate the fate of hematopoietic progenitor cells in a complex and context-dependent manner. Growth differentiation factor-15 (GDF15) is a divergent member of the TGF-beta family. This stress-induced cytokine has been proposed to possess immunomodulatory functions and its high expression is often associated with progression of a variety of pathological conditions. GDF15 is also induced by chemotherapy and irradiation. Very few fundamental studies have been published regarding the effect of GDF15 in hematopoiesis. In this study, we analyzed the hematological status of untreated and gamma-irradiated mice deficient for GDF15 as a result of genetic knock-out (KO), in order to clarify the regulatory role of GDF15 in hematopoiesis. Significant differences between GDF15 KO mice and their pertinent WT controls were found in the parameters of blood monocyte numbers, blood platelet size, and distribution width, as well as in the values of bone marrow granulocyte/macrophage progenitor cells. Different tendencies of some hematological parameters in the GDF15 KO mice in normal conditions and those under exposure of the mice to ionizing radiation were registered. These findings are discussed in the context of the GDF15 gene function and its lack under conditions of radiation-induced damage.

Links

EE2.3.20.0185, research and development project

Name: Centrum analýz a modelování tkání a orgánů

GA15-11707S, research and development project

Name: Centrosomální abnormality u lidských pluripotentních kmenových buněk.

Investor: Czech Science Foundation

GA16-12454S, research and development project

Name: Charakterizace a modifikace komplexní odpovědi buněk nádorů hlavy a krku na různá záření - krok kupředu ke kombinované personalizované (radio)terapii

Investor: Czech Science Foundation

NV15-33999A, research and development project

Name: Vývoj nových nízkomolekulárních protinádorových léčiv na principu syntetické letality

Citovat

HOFER, M., Z. HOFEROVA, Ján REMŠÍK, M. NOVAKOVA, J. PROCHAZKOVA, R. FEDR, J. KOHOUTEK, Ladislav DUŠEK, Aleš HAMPL and K. SOUČEK. Hematological Findings in Non-Treated and gamma-Irradiated Mice Deficient for MIC-1/GDF15. Physiological research. Praha: Fyziologický ústav AV ČR, 2018, vol. 67, No 4, p. 623-636. ISSN 0862-8408.

@article{1479636,
   author = {Hofer, M. and Hoferova, Z. and Remšík, Ján and Novakova, M. and Prochazkova, J. and Fedr, R. and Kohoutek, J. and Dušek, Ladislav and Hampl, Aleš and Souček, K.},
   article_location = {Praha},
   article_number = {4},
   keywords = {GDF15 knockout mice; Hematopoiesis; Ionizing radiation; Stress-induced cytokine},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological research},
   title = {Hematological Findings in Non-Treated and gamma-Irradiated Mice Deficient for MIC-1/GDF15},
   volume = {67},
   year = {2018}
}

TY  - JOUR
ID  - 1479636
AU  - Hofer, M. - Hoferova, Z. - Remšík, Ján - Novakova, M. - Prochazkova, J. - Fedr, R. - Kohoutek, J. - Dušek, Ladislav - Hampl, Aleš - Souček, K.
PY  - 2018
TI  - Hematological Findings in Non-Treated and gamma-Irradiated Mice Deficient for MIC-1/GDF15
JF  - Physiological research
VL  - 67
IS  - 4
SP  - 623-636
EP  - 623-636
PB  - Fyziologický ústav AV ČR
SN  - 08628408
KW  - GDF15 knockout mice
KW  - Hematopoiesis
KW  - Ionizing radiation
KW  - Stress-induced cytokine
N2  - Several members of the TGF-beta family are known to effectively regulate the fate of hematopoietic progenitor cells in a complex and context-dependent manner. Growth differentiation factor-15 (GDF15) is a divergent member of the TGF-beta family. This stress-induced cytokine has been proposed to possess immunomodulatory functions and its high expression is often associated with progression of a variety of pathological conditions. GDF15 is also induced by chemotherapy and irradiation. Very few fundamental studies have been published regarding the effect of GDF15 in hematopoiesis. In this study, we analyzed the hematological status of untreated and gamma-irradiated mice deficient for GDF15 as a result of genetic knock-out (KO), in order to clarify the regulatory role of GDF15 in hematopoiesis. Significant differences between GDF15 KO mice and their pertinent WT controls were found in the parameters of blood monocyte numbers, blood platelet size, and distribution width, as well as in the values of bone marrow granulocyte/macrophage progenitor cells. Different tendencies of some hematological parameters in the GDF15 KO mice in normal conditions and those under exposure of the mice to ionizing radiation were registered. These findings are discussed in the context of the GDF15 gene function and its lack under conditions of radiation-induced damage.
ER  -

HOFER, M., Z. HOFEROVA, Ján REMŠÍK, M. NOVAKOVA, J. PROCHAZKOVA, R. FEDR, J. KOHOUTEK, Ladislav DUŠEK, Aleš HAMPL and K. SOUČEK. Hematological Findings in Non-Treated and gamma-Irradiated Mice Deficient for MIC-1/GDF15. \textit{Physiological research}. Praha: Fyziologický ústav AV ČR, 2018, vol.~67, No~4, p.~623-636. ISSN~0862-8408.

Detailed Information on Publication Record