PISKÁČEK, Martin, Marek HAVELKA, Kristína JENDRUCHOVÁ and Andrea KNIGHT. Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways. Journal of steroid biochemistry and molecular biology. Oxford: Pergamon-Elsevier Science, 2019, vol. 187, MAR 2019, p. 118-123. ISSN 0960-0760. Available from: https://dx.doi.org/10.1016/j.jsbmb.2018.11.008.
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Basic information
Original name Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways
Authors PISKÁČEK, Martin (40 Austria, belonging to the institution), Marek HAVELKA (203 Czech Republic, belonging to the institution), Kristína JENDRUCHOVÁ (703 Slovakia, belonging to the institution) and Andrea KNIGHT (203 Czech Republic, belonging to the institution).
Edition Journal of steroid biochemistry and molecular biology, Oxford, Pergamon-Elsevier Science, 2019, 0960-0760.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10608 Biochemistry and molecular biology
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 3.813
RIV identification code RIV/00216224:14110/19:00108447
Organization unit Faculty of Medicine
Doi http://dx.doi.org/10.1016/j.jsbmb.2018.11.008
UT WoS 000459952100015
Keywords in English 9aaTAD; CBP; HNF4; KIX; MED15; PPAR; RARa; VDL
Tags 14110518, rivok
Tags International impact, Reviewed
Changed by Changed by: Soňa Böhmová, učo 232884. Changed: 16/4/2019 16:14.
Abstract
In higher metazoans, the nuclear hormone receptors activate transcription trough their specific adaptors, nuclear hormone receptor adaptors NCoA, which are absent in lower metazoans. The Nine amino acid TransActivation Domain, 9aaTAD, was reported for a large number of the transcription activators that recruit general mediators of transcription. In this study, we demonstrated that the 9aaTAD from NHR-49 receptor of nematode C.elegans activates transcription as a small peptide. We showed that the ancient 9aaTAD domains are conserved in the nuclear hormone receptors including human HNF4, RARa, VDR and PPARg. Also their small 9aaTAD peptides effectively activated transcription in absence of the NCoA adaptors. We also showed that adjacent H11 domains in ancient and modern hormone receptors have an inhibitory effect on their 9aaTAD function.
Links
NV15-32935A, research and development projectName: Analýza gamma-delta T lymfocytů reaktivních na nádorové buňky u pacientů s B-buněčnou chronickou lymfocytární leukémií: nový přístup k buněčné terapii
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