Relationship of epigenetic variability of miR-124 to
extracellular matrix remodelling and age-related MMP-3
expression in rheumatoid arthritis

J 2018

Relationship of epigenetic variability of miR-124 to extracellular matrix remodelling and age-related MMP-3 expression in rheumatoid arthritis

PÁVKOVÁ GOLDBERGOVÁ, Monika, Jolana LIPKOVÁ, Jan FEDORKO, Petr NĚMEC, Jindřiška GATTEROVÁ et. al.

Basic information

Original name

Relationship of epigenetic variability of miR-124 to extracellular matrix remodelling and age-related MMP-3 expression in rheumatoid arthritis

Authors

PÁVKOVÁ GOLDBERGOVÁ, Monika (203 Czech Republic, guarantor, belonging to the institution), Jolana LIPKOVÁ (203 Czech Republic, belonging to the institution), Jan FEDORKO (203 Czech Republic, belonging to the institution), Petr NĚMEC (203 Czech Republic, belonging to the institution), Jindřiška GATTEROVÁ (203 Czech Republic), Lucie VÁLKOVÁ (203 Czech Republic, belonging to the institution), Jana VEVERKOVÁ (203 Czech Republic, belonging to the institution) and Anna VAŠKŮ (203 Czech Republic, belonging to the institution)

Edition

General physiology and biophysics, Bratislava, Ústav molekulárnej fyziológie a genetiky SAV, 2018, 0231-5882

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.309

RIV identification code

RIV/00216224:14110/18:00104962

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.4149/gpb_2018024

UT WoS

000453646800010

Keywords in English

Rheumatoid arthritis; Protein; microRNA; Expression; MMP

Abstract

V originále

The aim of study was to examine relation among miR-124 and serum levels of selected cytokines and chemokines, MMP-3, production of auto-antibodies, and factors describing clinical activity (DAS28) and radiographic progression in rheumatoid arthritis (RA). A total of 80 RA patients according to the ACR classification criteria, and 32 control subjects were recruited into study. The measurements of miR-124 and U-6 expression, CRP anti-CCP, rheumatoid factors (RFs), radiographs of both hands with calculation of total sharp score (TSS), DAS28 and cytokines, chemokines and MMP levels in serum were obtained from all RA patients. miR-124 was down-regulated in RA patients compared to controls (7-fold decrease). The miR-124 expression correlated to MMP-3 levels (p < 0.001), which were in multivariate analysis associated to age of RA onset. Higher levels were detected in younger subjects. No relation of miR-124 expression to measures of RA activity (DAS28 score; TSS), auto-antibodies (anti-CCP, RR, RF IgG, RF IgA, RF IgM), acute inflammatory markers (CRP, IL-6), and other cytokine and chemokines (IL-13, IL-15, IL-8, TNF-alpha, MCP-1, RANTES) was observed. In conclusion, we present a down-regulation of miR-124 in RA patients and its correlation to MMP-3 levels, which associated to age of RA onset.

Links

MUNI/A/1297/2017, interní kód MU

Name: Tkáňové aspekty patofyziologických stavů (Acronym: patologická tkáň)

Investor: Masaryk University, Category A

Citovat

PÁVKOVÁ GOLDBERGOVÁ, Monika, Jolana LIPKOVÁ, Jan FEDORKO, Petr NĚMEC, Jindřiška GATTEROVÁ, Lucie VÁLKOVÁ, Jana VEVERKOVÁ and Anna VAŠKŮ. Relationship of epigenetic variability of miR-124 to extracellular matrix remodelling and age-related MMP-3 expression in rheumatoid arthritis. General physiology and biophysics. Bratislava: Ústav molekulárnej fyziológie a genetiky SAV, 2018, vol. 37, No 6, p. 703-710. ISSN 0231-5882. Available from: https://dx.doi.org/10.4149/gpb_2018024.

@article{1479859,
   author = {Pávková Goldbergová, Monika and Lipková, Jolana and Fedorko, Jan and Němec, Petr and Gatterová, Jindřiška and Válková, Lucie and Veverková, Jana and Vašků, Anna},
   article_location = {Bratislava},
   article_number = {6},
   doi = {http://dx.doi.org/10.4149/gpb_2018024},
   keywords = {Rheumatoid arthritis; Protein; microRNA; Expression; MMP},
   language = {eng},
   issn = {0231-5882},
   journal = {General physiology and biophysics},
   title = {Relationship of epigenetic variability of miR-124 to extracellular matrix remodelling and age-related MMP-3 expression in rheumatoid arthritis},
   volume = {37},
   year = {2018}
}

TY  - JOUR
ID  - 1479859
AU  - Pávková Goldbergová, Monika - Lipková, Jolana - Fedorko, Jan - Němec, Petr - Gatterová, Jindřiška - Válková, Lucie - Veverková, Jana - Vašků, Anna
PY  - 2018
TI  - Relationship of epigenetic variability of miR-124 to extracellular matrix remodelling and age-related MMP-3 expression in rheumatoid arthritis
JF  - General physiology and biophysics
VL  - 37
IS  - 6
SP  - 703-710
EP  - 703-710
PB  - Ústav molekulárnej fyziológie a genetiky SAV
SN  - 02315882
KW  - Rheumatoid arthritis
KW  - Protein
KW  - microRNA
KW  - Expression
KW  - MMP
N2  - The aim of study was to examine relation among miR-124 and serum levels of selected cytokines and chemokines, MMP-3, production of auto-antibodies, and factors describing clinical activity (DAS28) and radiographic progression in rheumatoid arthritis (RA). A total of 80 RA patients according to the ACR classification criteria, and 32 control subjects were recruited into study. The measurements of miR-124 and U-6 expression, CRP anti-CCP, rheumatoid factors (RFs), radiographs of both hands with calculation of total sharp score (TSS), DAS28 and cytokines, chemokines and MMP levels in serum were obtained from all RA patients. miR-124 was down-regulated in RA patients compared to controls (7-fold decrease). The miR-124 expression correlated to MMP-3 levels (p < 0.001), which were in multivariate analysis associated to age of RA onset. Higher levels were detected in younger subjects. No relation of miR-124 expression to measures of RA activity (DAS28 score; TSS), auto-antibodies (anti-CCP, RR, RF IgG, RF IgA, RF IgM), acute inflammatory markers (CRP, IL-6), and other cytokine and chemokines (IL-13, IL-15, IL-8, TNF-alpha, MCP-1, RANTES) was observed. In conclusion, we present a down-regulation of miR-124 in RA patients and its correlation to MMP-3 levels, which associated to age of RA onset.
ER  -

PÁVKOVÁ GOLDBERGOVÁ, Monika, Jolana LIPKOVÁ, Jan FEDORKO, Petr NĚMEC, Jindřiška GATTEROVÁ, Lucie VÁLKOVÁ, Jana VEVERKOVÁ and Anna VAŠKŮ. Relationship of epigenetic variability of miR-124 to extracellular matrix remodelling and age-related MMP-3 expression in rheumatoid arthritis. \textit{General physiology and biophysics}. Bratislava: Ústav molekulárnej fyziológie a genetiky SAV, 2018, vol.~37, No~6, p.~703-710. ISSN~0231-5882. Available from: https://dx.doi.org/10.4149/gpb\_{}2018024.

Detailed Information on Publication Record