CIBULA, D., N.R. ABU-RUSTUM, D. FISCHEROVA, S. PATHER, K. LAVIGNE, J. SLAMA, K. ALEKTIAR, L. MING-YIN, R. KOCIAN, A. GERMANOVA, F. FRÜHAUF, L. DOSTALEK, Ladislav DUŠEK and K. NARAYAN. Surgical treatment of “intermediate risk” lymph node negative cervical cancer patients without adjuvant radiotherapy – A retrospective cohort study and review of the literature. Gynecologic Oncology. San Diego: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018, vol. 151, No 3, p. 438-443. ISSN 0090-8258. Available from: https://dx.doi.org/10.1016/j.ygyno.2018.10.018. |
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@article{1479872, author = {Cibula, D. and AbuandRustum, N.R. and Fischerova, D. and Pather, S. and Lavigne, K. and Slama, J. and Alektiar, K. and MingandYin, L. and Kocian, R. and Germanova, A. and Frühauf, F. and Dostalek, L. and Dušek, Ladislav and Narayan, K.}, article_location = {San Diego}, article_number = {3}, doi = {http://dx.doi.org/10.1016/j.ygyno.2018.10.018}, keywords = {lymph node negative cervical cancer}, language = {eng}, issn = {0090-8258}, journal = {Gynecologic Oncology}, title = {Surgical treatment of “intermediate risk” lymph node negative cervical cancer patients without adjuvant radiotherapy – A retrospective cohort study and review of the literature}, volume = {151}, year = {2018} }
TY - JOUR ID - 1479872 AU - Cibula, D. - Abu-Rustum, N.R. - Fischerova, D. - Pather, S. - Lavigne, K. - Slama, J. - Alektiar, K. - Ming-Yin, L. - Kocian, R. - Germanova, A. - Frühauf, F. - Dostalek, L. - Dušek, Ladislav - Narayan, K. PY - 2018 TI - Surgical treatment of “intermediate risk” lymph node negative cervical cancer patients without adjuvant radiotherapy – A retrospective cohort study and review of the literature JF - Gynecologic Oncology VL - 151 IS - 3 SP - 438-443 EP - 438-443 PB - ACADEMIC PRESS INC ELSEVIER SCIENCE SN - 00908258 KW - lymph node negative cervical cancer N2 - Objectives. The role of adjuvant radiotherapy for lymph node-negative stage IB patients with tumor-related negative prognostic factors is not uniformly accepted. It is advocated based on the GOG 92 trial, which was initiated in 1989. The aim of the current study is to report the oncological outcome of "intermediate risk" patients treated by tailored surgery without adjuvant radiotherapy. Data from two institutions that refer these patients for adjuvant radiotherapy served as a control group. Methods. Included were patients with stage IB cervical cancer treated with radical hysterectomy and pelvic lymphadenectomy, who had negative pelvic lymph nodes but a combination of negative prognostic factors adopted from the GOG 92 trial. Data were obtained from prospectively collected databases of three institutions. Radical surgery was a single-treatment modality in one of them and in the remaining two institutes it was followed by adjuvant chemoradiation. Results. In 127 patients who received only radical surgery, with a median follow-up of 6.1 years, the local recurrence rate was 1.6% (2 cases), and total recurrence was 6.3% (8 cases). Disease-specific survival at 5 years was 95.7% (91.9%: 99.4%) and 91% (83.7%; 98.3%) at 10 years. The only significant factor for disease-specific survival was tumor size >= 4 cm (P = 0.032). The recurrence rate, local control or overall survival did not differ from the control group. Adjuvant radiotherapy was not a significant prognostic factor within the whole cohort. Conclusions. An excellent oncological outcome, especially local control, can be achieved by both radical surgery or combined treatment in stage IB lymph node-negative cervical cancer patients with negative prognostic factors. The substantially better outcome than in the GOG 92 trial can be attributed to more accurate pre-operative and pathological staging and an improvement in surgical techniques. ER -
CIBULA, D., N.R. ABU-RUSTUM, D. FISCHEROVA, S. PATHER, K. LAVIGNE, J. SLAMA, K. ALEKTIAR, L. MING-YIN, R. KOCIAN, A. GERMANOVA, F. FRÜHAUF, L. DOSTALEK, Ladislav DUŠEK and K. NARAYAN. Surgical treatment of “intermediate risk” lymph node negative cervical cancer patients without adjuvant radiotherapy – A retrospective cohort study and review of the literature. \textit{Gynecologic Oncology}. San Diego: ACADEMIC PRESS INC ELSEVIER SCIENCE, 2018, vol.~151, No~3, p.~438-443. ISSN~0090-8258. Available from: https://dx.doi.org/10.1016/j.ygyno.2018.10.018.
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