| HOKYNKOVÁ, Alica, Zdeněk WILHELM, Marie NOVÁKOVÁ, Petr BABULA, Tibor STRAČINA, Hana PAULOVÁ, Miroslava HLAVÁČOVÁ and Miroslava SEDLÁČKOVÁ. Wound healing effects after application of polyunsaturated fatty acids in rat (Wound healing effects after application of polyunsaturated fatty acids in rat). Česká a slovenská neurologie a neurochirurgie. Praha: Česká lékařská společnost J.E. Purkyně, 2018, vol. 81, Suppl. 1, p. "S29"-"S31", 3 pp. ISSN 1210-7859. Available from: https://dx.doi.org/10.14735/amcsnn2018S29. |
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@article{1479976,
author = {Hokynková, Alica and Wilhelm, Zdeněk and Nováková, Marie and Babula, Petr and Stračina, Tibor and Paulová, Hana and Hlaváčová, Miroslava and Sedláčková, Miroslava},
article_location = {Praha},
article_number = {Suppl. 1},
doi = {http://dx.doi.org/10.14735/amcsnn2018S29},
keywords = {polyunsaturated fatty acids; wound healing; anti-oxidative capacity; 4-1-INE; 4-hydroxy-2-nonenal},
language = {sla},
issn = {1210-7859},
journal = {Česká a slovenská neurologie a neurochirurgie},
title = {Wound healing effects after application of polyunsaturated fatty acids in rat},
url = {http://dx.doi.org/10.14735/amcsnn2018S29},
volume = {81},
year = {2018}
}
TY - JOUR
ID - 1479976
AU - Hokynková, Alica - Wilhelm, Zdeněk - Nováková, Marie - Babula, Petr - Stračina, Tibor - Paulová, Hana - Hlaváčová, Miroslava - Sedláčková, Miroslava
PY - 2018
TI - Wound healing effects after application of polyunsaturated fatty acids in rat
JF - Česká a slovenská neurologie a neurochirurgie
VL - 81
IS - Suppl. 1
SP - "S29"-"S31"
EP - "S29"-"S31"
PB - Česká lékařská společnost J.E. Purkyně
SN - 12107859
KW - polyunsaturated fatty acids
KW - wound healing
KW - anti-oxidative capacity
KW - 4-1-INE
KW - 4-hydroxy-2-nonenal
UR - http://dx.doi.org/10.14735/amcsnn2018S29
N2 - Introduction: Although mechanisms of polyunsaturated fatty acids influence on skin wound heal- ing have not been fully elucidated yet, it is undisputable that nutritional state affects it profoundly. Aim: The study was focused on speed and quality of wound healing influenced by short-lasting oral administration of omega-3 and omega-6 polyunsaturated fatty acids. Materials and methods: Young Wistar rats received by orogastric tube either 20% fat emulsion (experimental groups E and F differed by ratio between omega-3 : omega-6 : omega-9 polyunsaturated fatty acids) or water (control group C). After 7 days, skin wound on back was performed and emulsion or water application continued for another week. Blood and tissue samples were obtained during experiment termination. Plasmatic levels of fatty acids, 4-hydroxy-2-nonenal and oxidative stress both in plasma and in wound tissue were examined. Speed and quality of wound healing were assessed by digital planimetry and histological examination. Results were statistically evaluated by non-parametric tests. Results: Significant changes of fatty acids plasmatic levels were observed in animals in experimental groups as well as better ability of their plasma and tissues to cope with oxidative stress. Conclusion: Short-lasting administration of certain ratio of polyunsaturated fatty acids positively affects skin wound healing.
ER -
HOKYNKOVÁ, Alica, Zdeněk WILHELM, Marie NOVÁKOVÁ, Petr BABULA, Tibor STRAČINA, Hana PAULOVÁ, Miroslava HLAVÁČOVÁ and Miroslava SEDLÁČKOVÁ. Wound healing effects after application of polyunsaturated fatty acids in rat (Wound healing effects after application of polyunsaturated fatty acids in rat). \textit{Česká a slovenská neurologie a neurochirurgie}. Praha: Česká lékařská společnost J.E. Purkyně, 2018, vol.~81, Suppl. 1, p.~''S29''-''S31'', 3 pp. ISSN~1210-7859. Available from: https://dx.doi.org/10.14735/amcsnn2018S29.
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