Detailed Information on Publication Record
2018
Wound healing effects after application of polyunsaturated fatty acids in rat
HOKYNKOVÁ, Alica, Zdeněk WILHELM, Marie NOVÁKOVÁ, Petr BABULA, Tibor STRAČINA et. al.Basic information
Original name
Wound healing effects after application of polyunsaturated fatty acids in rat
Name in Czech
Změny v kvalitě hojení ran po podání nenasycených mastných kyselin u potkana
Name (in English)
Wound healing effects after application of polyunsaturated fatty acids in rat
Authors
HOKYNKOVÁ, Alica (703 Slovakia, belonging to the institution), Zdeněk WILHELM (203 Czech Republic, belonging to the institution), Marie NOVÁKOVÁ (203 Czech Republic, belonging to the institution), Petr BABULA (203 Czech Republic, belonging to the institution), Tibor STRAČINA (703 Slovakia, belonging to the institution), Hana PAULOVÁ (203 Czech Republic, belonging to the institution), Miroslava HLAVÁČOVÁ (703 Slovakia, belonging to the institution) and Miroslava SEDLÁČKOVÁ (203 Czech Republic, belonging to the institution)
Edition
Česká a slovenská neurologie a neurochirurgie, Praha, Česká lékařská společnost J.E. Purkyně, 2018, 1210-7859
Other information
Language
Slovak
Type of outcome
Článek v odborném periodiku
Field of Study
30105 Physiology
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 0.355
RIV identification code
RIV/00216224:14110/18:00104972
Organization unit
Faculty of Medicine
UT WoS
000452867800005
Keywords (in Czech)
nenasycené mastné kyseliny; hojení ran; antioxidační kapacita; 4-HNE; 4-hydroxy-2-nonenal
Keywords in English
polyunsaturated fatty acids; wound healing; anti-oxidative capacity; 4-1-INE; 4-hydroxy-2-nonenal
Tags
International impact, Reviewed
Změněno: 23/4/2024 10:08, Mgr. Michal Petr
V originále
Introduction: Although mechanisms of polyunsaturated fatty acids influence on skin wound heal- ing have not been fully elucidated yet, it is undisputable that nutritional state affects it profoundly. Aim: The study was focused on speed and quality of wound healing influenced by short-lasting oral administration of omega-3 and omega-6 polyunsaturated fatty acids. Materials and methods: Young Wistar rats received by orogastric tube either 20% fat emulsion (experimental groups E and F differed by ratio between omega-3 : omega-6 : omega-9 polyunsaturated fatty acids) or water (control group C). After 7 days, skin wound on back was performed and emulsion or water application continued for another week. Blood and tissue samples were obtained during experiment termination. Plasmatic levels of fatty acids, 4-hydroxy-2-nonenal and oxidative stress both in plasma and in wound tissue were examined. Speed and quality of wound healing were assessed by digital planimetry and histological examination. Results were statistically evaluated by non-parametric tests. Results: Significant changes of fatty acids plasmatic levels were observed in animals in experimental groups as well as better ability of their plasma and tissues to cope with oxidative stress. Conclusion: Short-lasting administration of certain ratio of polyunsaturated fatty acids positively affects skin wound healing.
In English
Although mechanisms of fatty acids influence on skin wound healing has not been fully elucidated yet, it is undisputable that nutritional state affects it profoundly. The study was focused on speed and quality of wound healing influenced by short-lasting oral administration of omega-3 and omega-6 polyunsaturated fatty acids. Young Wistar rats received by orogastric tube either 20% fat emulsion (experimental groups E and F differed by ratio between omega-3:omega-6:omega-9 polyunsaturated fatty acids) or water (control group C). After 7 days, skin wound on back was performed and emulsion or water application continued for another week. Blood and tissue samples were obtained during experiment termination. Plasmatic levels of fatty acids, 4-hydroxy-2-nonenal and oxidative stress both in plasma and in wound tissue were examined. Speed and quality of wound healing were assessed by digital planimetry and histological examination. Results were statistically evaluated by non-parametric tests. Significant changes of fatty acids plasmatic levels were observed in animals in experimental groups as well as better ability of their plasma and tissues to cope with oxidative stress. Short-lasting administration of certain ratio of polyunsaturated fatty acids positively affects skin wound healing.
Links
| MUNI/A/0910/2017, interní kód MU |
| ||
| MUNI/A/1157/2017, interní kód MU |
|