HOKYNKOVÁ, Alica, Zdeněk WILHELM, Marie NOVÁKOVÁ, Petr BABULA, Tibor STRAČINA, Hana PAULOVÁ, Miroslava HLAVÁČOVÁ and Miroslava SEDLÁČKOVÁ. Wound healing effects after application of polyunsaturated fatty acids in rat (Wound healing effects after application of polyunsaturated fatty acids in rat). Česká a slovenská neurologie a neurochirurgie. Praha: Česká lékařská společnost J.E. Purkyně, 2018, vol. 81, Suppl. 1, p. "S29"-"S31", 3 pp. ISSN 1210-7859. Available from: https://dx.doi.org/10.14735/amcsnn2018S29. |
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@article{1479976, author = {Hokynková, Alica and Wilhelm, Zdeněk and Nováková, Marie and Babula, Petr and Stračina, Tibor and Paulová, Hana and Hlaváčová, Miroslava and Sedláčková, Miroslava}, article_location = {Praha}, article_number = {Suppl. 1}, doi = {http://dx.doi.org/10.14735/amcsnn2018S29}, keywords = {polyunsaturated fatty acids; wound healing; anti-oxidative capacity; 4-1-INE; 4-hydroxy-2-nonenal}, language = {sla}, issn = {1210-7859}, journal = {Česká a slovenská neurologie a neurochirurgie}, title = {Wound healing effects after application of polyunsaturated fatty acids in rat}, url = {http://dx.doi.org/10.14735/amcsnn2018S29}, volume = {81}, year = {2018} }
TY - JOUR ID - 1479976 AU - Hokynková, Alica - Wilhelm, Zdeněk - Nováková, Marie - Babula, Petr - Stračina, Tibor - Paulová, Hana - Hlaváčová, Miroslava - Sedláčková, Miroslava PY - 2018 TI - Wound healing effects after application of polyunsaturated fatty acids in rat JF - Česká a slovenská neurologie a neurochirurgie VL - 81 IS - Suppl. 1 SP - "S29"-"S31" EP - "S29"-"S31" PB - Česká lékařská společnost J.E. Purkyně SN - 12107859 KW - polyunsaturated fatty acids KW - wound healing KW - anti-oxidative capacity KW - 4-1-INE KW - 4-hydroxy-2-nonenal UR - http://dx.doi.org/10.14735/amcsnn2018S29 N2 - Introduction: Although mechanisms of polyunsaturated fatty acids influence on skin wound heal- ing have not been fully elucidated yet, it is undisputable that nutritional state affects it profoundly. Aim: The study was focused on speed and quality of wound healing influenced by short-lasting oral administration of omega-3 and omega-6 polyunsaturated fatty acids. Materials and methods: Young Wistar rats received by orogastric tube either 20% fat emulsion (experimental groups E and F differed by ratio between omega-3 : omega-6 : omega-9 polyunsaturated fatty acids) or water (control group C). After 7 days, skin wound on back was performed and emulsion or water application continued for another week. Blood and tissue samples were obtained during experiment termination. Plasmatic levels of fatty acids, 4-hydroxy-2-nonenal and oxidative stress both in plasma and in wound tissue were examined. Speed and quality of wound healing were assessed by digital planimetry and histological examination. Results were statistically evaluated by non-parametric tests. Results: Significant changes of fatty acids plasmatic levels were observed in animals in experimental groups as well as better ability of their plasma and tissues to cope with oxidative stress. Conclusion: Short-lasting administration of certain ratio of polyunsaturated fatty acids positively affects skin wound healing. ER -
HOKYNKOVÁ, Alica, Zdeněk WILHELM, Marie NOVÁKOVÁ, Petr BABULA, Tibor STRAČINA, Hana PAULOVÁ, Miroslava HLAVÁČOVÁ and Miroslava SEDLÁČKOVÁ. Wound healing effects after application of polyunsaturated fatty acids in rat (Wound healing effects after application of polyunsaturated fatty acids in rat). \textit{Česká a slovenská neurologie a neurochirurgie}. Praha: Česká lékařská společnost J.E. Purkyně, 2018, vol.~81, Suppl. 1, p.~''S29''-''S31'', 3 pp. ISSN~1210-7859. Available from: https://dx.doi.org/10.14735/amcsnn2018S29.
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