| PLESKAČOVÁ, Anna, Vendula BARTÁKOVÁ, Katarína CHALÁSOVÁ, Lukáš PÁCAL, Kateřina KAŇKOVÁ a Josef TOMANDL. Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes. International Journal of Molecular Sciences. Basel: MDPI AG, 2018, roč. 19, č. 11, s. 1-13. ISSN 1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms19113696. |
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@article{1480138,
author = {Pleskačová, Anna and Bartáková, Vendula and Chalásová, Katarína and Pácal, Lukáš and Kaňková, Kateřina and Tomandl, Josef},
article_location = {Basel},
article_number = {11},
doi = {http://dx.doi.org/10.3390/ijms19113696},
keywords = {uric acid; uricemia; xanthine; gestational diabetes mellitus; pregnancy; adverse perinatal outcomes},
language = {eng},
issn = {1422-0067},
journal = {International Journal of Molecular Sciences},
title = {Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes},
volume = {19},
year = {2018}
}
TY - JOUR
ID - 1480138
AU - Pleskačová, Anna - Bartáková, Vendula - Chalásová, Katarína - Pácal, Lukáš - Kaňková, Kateřina - Tomandl, Josef
PY - 2018
TI - Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes
JF - International Journal of Molecular Sciences
VL - 19
IS - 11
SP - 1-13
EP - 1-13
PB - MDPI AG
SN - 14220067
KW - uric acid
KW - uricemia
KW - xanthine
KW - gestational diabetes mellitus
KW - pregnancy
KW - adverse perinatal outcomes
N2 - Uric acid (UA) levels are associated with many diseases including those related to lifestyle. The aim of this study was to evaluate the influence of clinical and anthropometric parameters on UA and xanthine (X) levels during pregnancy and postpartum in women with physiological pregnancy and pregnancy complicated by gestational diabetes mellitus (GDM), and to evaluate their impact on adverse perinatal outcomes. A total of 143 participants were included. Analyte levels were determined by HPLC with ultraviolet detection (HPLC-UV). Several single-nucleotide polymorphisms (SNPs) in UA transporters were genotyped using commercial assays. UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. X levels were higher in the GDM group during pregnancy and also postpartum. Positive correlations between UA and X levels with body mass index (BMI) and glycemia levels were found. Gestational age at delivery was negatively correlated with UA and X levels postpartum. Postpartum X levels were significantly higher in women who underwent caesarean sections. Our data support a possible link between increased UA levels and a high-risk GDM subtype. UA levels were higher among women whose glucose tolerance was severely disturbed. Mid-gestational UA and X levels were not linked to adverse perinatal outcomes.
ER -
PLESKAČOVÁ, Anna, Vendula BARTÁKOVÁ, Katarína CHALÁSOVÁ, Lukáš PÁCAL, Kateřina KAŇKOVÁ a Josef TOMANDL. Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes. \textit{International Journal of Molecular Sciences}. Basel: MDPI AG, 2018, roč.~19, č.~11, s.~1-13. ISSN~1422-0067. Dostupné z: https://dx.doi.org/10.3390/ijms19113696.
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