Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes

PLESKAČOVÁ, Anna, Vendula BARTÁKOVÁ, Katarína CHALÁSOVÁ, Lukáš PÁCAL, Kateřina KAŇKOVÁ and Josef TOMANDL. Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes. International Journal of Molecular Sciences. Basel: MDPI AG, 2018, vol. 19, No 11, p. 1-13. ISSN 1422-0067. Available from: https://dx.doi.org/10.3390/ijms19113696.

Basic information

• Original name: Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes
• Authors: PLESKAČOVÁ, Anna (203 Czech Republic, belonging to the institution), Vendula BARTÁKOVÁ (203 Czech Republic, belonging to the institution), Katarína CHALÁSOVÁ (703 Slovakia, belonging to the institution), Lukáš PÁCAL (203 Czech Republic, belonging to the institution), Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution) and Josef TOMANDL (203 Czech Republic, guarantor, belonging to the institution).
• Edition: International Journal of Molecular Sciences, Basel, MDPI AG, 2018, 1422-0067.

Other information

• Original language: English
• Type of outcome: Article in a journal
• Field of Study: 10608 Biochemistry and molecular biology
• Country of publisher: Switzerland
• Confidentiality degree: is not subject to a state or trade secret
• Impact factor: Impact factor: 4.183
• RIV identification code: RIV/00216224:14110/18:00106957
• Organization unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.3390/ijms19113696
• UT WoS: 000451528500411
• Keywords in English: uric acid; uricemia; xanthine; gestational diabetes mellitus; pregnancy; adverse perinatal outcomes
• Tags: 14110512, 14110518, rivok
• Tags: International impact, Reviewed

Abstract

Uric acid (UA) levels are associated with many diseases including those related to lifestyle. The aim of this study was to evaluate the influence of clinical and anthropometric parameters on UA and xanthine (X) levels during pregnancy and postpartum in women with physiological pregnancy and pregnancy complicated by gestational diabetes mellitus (GDM), and to evaluate their impact on adverse perinatal outcomes. A total of 143 participants were included. Analyte levels were determined by HPLC with ultraviolet detection (HPLC-UV). Several single-nucleotide polymorphisms (SNPs) in UA transporters were genotyped using commercial assays. UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. X levels were higher in the GDM group during pregnancy and also postpartum. Positive correlations between UA and X levels with body mass index (BMI) and glycemia levels were found. Gestational age at delivery was negatively correlated with UA and X levels postpartum. Postpartum X levels were significantly higher in women who underwent caesarean sections. Our data support a possible link between increased UA levels and a high-risk GDM subtype. UA levels were higher among women whose glucose tolerance was severely disturbed. Mid-gestational UA and X levels were not linked to adverse perinatal outcomes.

Links

• MUNI/A/0910/2017, interní kód MU: Name: Studium molekulární podstaty vybraných patologických stavů a onemocnění (Acronym: stumopo)

Investor: Masaryk University, Category A

• NV16-28040A, research and development project: Name: Dlouhodobé dopady gestačního diabetes mellitus pro metabolické zdraví žen časně postpartum: význam nových diagnostických kritérií