J 2018

Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes

PLESKAČOVÁ, Anna, Vendula BARTÁKOVÁ, Katarína CHALÁSOVÁ, Lukáš PÁCAL, Kateřina KAŇKOVÁ et. al.

Basic information

Original name

Uric Acid and Xanthine Levels in Pregnancy Complicated by Gestational Diabetes MellitusThe Effect on Adverse Pregnancy Outcomes

Authors

PLESKAČOVÁ, Anna (203 Czech Republic, belonging to the institution), Vendula BARTÁKOVÁ (203 Czech Republic, belonging to the institution), Katarína CHALÁSOVÁ (703 Slovakia, belonging to the institution), Lukáš PÁCAL (203 Czech Republic, belonging to the institution), Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution) and Josef TOMANDL (203 Czech Republic, guarantor, belonging to the institution)

Edition

International Journal of Molecular Sciences, Basel, MDPI AG, 2018, 1422-0067

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10608 Biochemistry and molecular biology

Country of publisher

Switzerland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 4.183

RIV identification code

RIV/00216224:14110/18:00106957

Organization unit

Faculty of Medicine

DOI

UT WoS

000451528500411

Keywords in English

uric acid; uricemia; xanthine; gestational diabetes mellitus; pregnancy; adverse perinatal outcomes

Tags

Tags

International impact, Reviewed
Změněno: 11/2/2019 15:49, Soňa Böhmová

Abstract

V originále

Uric acid (UA) levels are associated with many diseases including those related to lifestyle. The aim of this study was to evaluate the influence of clinical and anthropometric parameters on UA and xanthine (X) levels during pregnancy and postpartum in women with physiological pregnancy and pregnancy complicated by gestational diabetes mellitus (GDM), and to evaluate their impact on adverse perinatal outcomes. A total of 143 participants were included. Analyte levels were determined by HPLC with ultraviolet detection (HPLC-UV). Several single-nucleotide polymorphisms (SNPs) in UA transporters were genotyped using commercial assays. UA levels were higher within GDM women with pre-gestational obesity, those in high-risk groups, and those who required insulin during pregnancy. X levels were higher in the GDM group during pregnancy and also postpartum. Positive correlations between UA and X levels with body mass index (BMI) and glycemia levels were found. Gestational age at delivery was negatively correlated with UA and X levels postpartum. Postpartum X levels were significantly higher in women who underwent caesarean sections. Our data support a possible link between increased UA levels and a high-risk GDM subtype. UA levels were higher among women whose glucose tolerance was severely disturbed. Mid-gestational UA and X levels were not linked to adverse perinatal outcomes.

Links

MUNI/A/0910/2017, interní kód MU
Name: Studium molekulární podstaty vybraných patologických stavů a onemocnění (Acronym: stumopo)
Investor: Masaryk University, Category A
NV16-28040A, research and development project
Name: Dlouhodobé dopady gestačního diabetes mellitus pro metabolické zdraví žen časně postpartum: význam nových diagnostických kritérií