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@article{1482336,
author = {Dobrovolný, Jan and Smrčka, Martin and Bienertová Vašků, Julie},
article_location = {New York},
article_number = {6},
doi = {http://dx.doi.org/10.1007/s10072-018-3398-y},
keywords = {Traumatic brain injury; Vitamin E; alpha-Tocopherol; Oxidative stress; Dementia; Lazaroids},
language = {eng},
issn = {1590-1874},
journal = {NEUROLOGICAL SCIENCES},
title = {Therapeutic potential of vitamin E and its derivatives in traumatic brain injury-associated dementia},
url = {https://link.springer.com/article/10.1007%2Fs10072-018-3398-y},
volume = {39},
year = {2018}
}
TY - JOUR
ID - 1482336
AU - Dobrovolný, Jan - Smrčka, Martin - Bienertová Vašků, Julie
PY - 2018
TI - Therapeutic potential of vitamin E and its derivatives in traumatic brain injury-associated dementia
JF - NEUROLOGICAL SCIENCES
VL - 39
IS - 6
SP - 989-998
EP - 989-998
PB - Springer
SN - 15901874
KW - Traumatic brain injury
KW - Vitamin E
KW - alpha-Tocopherol
KW - Oxidative stress
KW - Dementia
KW - Lazaroids
UR - https://link.springer.com/article/10.1007%2Fs10072-018-3398-y
L2 - https://link.springer.com/article/10.1007%2Fs10072-018-3398-y
N2 - Traumatic brain injury is one of the most common causes for intervention in neurosurgery. Apart from its acute consequence, it can represent a further burden on individuals as well as society by being associated with significant comorbidity-mainly earlyonset dementia. Oxidative stress is one of the crucial mechanisms conferring the damage to nervous tissue, and it is believed it could be, to some extent, influenced by dietary composition, largely by antioxidants contained in the diet. Under stressful conditions, cell-derived reactive oxygen species in the brain can induce the formation of lipid peroxides and the shifting of redox homeostasis. This review discusses the potential of vitamin E as a potent antioxidant and its derived molecules, including vitamin E-based lazaroids, in traumatic brain injury, summarizing the current state of knowledge of its role in TBI-associated dementia.
ER -
DOBROVOLNÝ, Jan, Martin SMRČKA and Julie BIENERTOVÁ VAŠKŮ. Therapeutic potential of vitamin E and its derivatives in traumatic brain injury-associated dementia. \textit{NEUROLOGICAL SCIENCES}. New York: Springer, vol.~39, No~6, p.~989-998. ISSN~1590-1874. doi:10.1007/s10072-018-3398-y. 2018.
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