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@article{1482484,
author = {Vašíčková, Kateřina and Moráň, Lukáš and Gurín, Dominik and Vaňhara, Petr},
article_location = {Heidelberg},
article_number = {3},
doi = {http://dx.doi.org/10.1007/s00441-018-2888-9},
keywords = {Ovarian surface epithelium; Endoplasmic reticulum stress; Unfolded protein response; Senescence; Tauroursodeoxycholic acid},
language = {eng},
issn = {0302-766X},
journal = {CELL AND TISSUE RESEARCH},
title = {Alleviation of endoplasmic reticulum stress by tauroursodeoxycholic acid delays senescence of mouse ovarian surface epithelium},
url = {https://link.springer.com/article/10.1007%2Fs00441-018-2888-9},
volume = {374},
year = {2018}
}
TY - JOUR
ID - 1482484
AU - Vašíčková, Kateřina - Moráň, Lukáš - Gurín, Dominik - Vaňhara, Petr
PY - 2018
TI - Alleviation of endoplasmic reticulum stress by tauroursodeoxycholic acid delays senescence of mouse ovarian surface epithelium
JF - CELL AND TISSUE RESEARCH
VL - 374
IS - 3
SP - 643-652
EP - 643-652
PB - Springer Verlag
SN - 0302766X
KW - Ovarian surface epithelium
KW - Endoplasmic reticulum stress
KW - Unfolded protein response
KW - Senescence
KW - Tauroursodeoxycholic acid
UR - https://link.springer.com/article/10.1007%2Fs00441-018-2888-9
N2 - Ovarian surface epithelium (OSE) forms a single layer of mostly cuboidal cells on surface of mammalian ovaries that is inherently exposed to cell stress evoked by tissue damage every ovulation and declines morphologically after menopause. Endoplasmic reticulum (ER) is a principal cell organelle involved in proteosynthesis, but also integrating various stress signals. ER stress evokes a conserved signaling pathway, the unfolded protein response (UPR), leading to cell death or adaptation to stress conditions. In this work, we document that mouse OSE suffers from ER stress during replicative senescence in vitro, develops abnormalities in ER and initiates UPR. Attenuation of ER stress in senescent OSE by tauroursodeoxycholic acid (TUDCA) reconditions ER architecture and leads to delayed onset of senescence. In summary, we show for the first time a mutual molecular link between ER stress response and replicative senescence leading to phenotypic changes of non-malignant ovarian surface epithelium.
ER -
VAŠÍČKOVÁ, Kateřina, Lukáš MORÁŇ, Dominik GURÍN and Petr VAŇHARA. Alleviation of endoplasmic reticulum stress by tauroursodeoxycholic acid delays senescence of mouse ovarian surface epithelium. \textit{CELL AND TISSUE RESEARCH}. Heidelberg: Springer Verlag, 2018, vol.~374, No~3, p.~643-652. ISSN~0302-766X. Available from: https://dx.doi.org/10.1007/s00441-018-2888-9.
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