Association of HLA class I type with prevalence and outcome of
patients with acute myeloid leukemia and mutated nucleophosmin

J 2018

Association of HLA class I type with prevalence and outcome of patients with acute myeloid leukemia and mutated nucleophosmin

KUZELOVA, Katerina, Barbora BRODSKA, Johannes SCHETELIG, Christoph ROLLING, Zdeněk RÁČIL et. al.

Basic information

Original name

Association of HLA class I type with prevalence and outcome of patients with acute myeloid leukemia and mutated nucleophosmin

Authors

KUZELOVA, Katerina (203 Czech Republic, guarantor), Barbora BRODSKA (203 Czech Republic), Johannes SCHETELIG (276 Germany), Christoph ROLLING (276 Germany), Zdeněk RÁČIL (203 Czech Republic, belonging to the institution), Juliane Stickel WALZ (276 Germany), Grzegorz HELBIG (616 Poland), Ota FUCHS (203 Czech Republic), Milena VRANA (203 Czech Republic), Pavla PECHERKOVA (203 Czech Republic), Cyril SALEK (203 Czech Republic) and Jiří MAYER (203 Czech Republic, belonging to the institution)

Edition

Plos one, San Francisco, Public Library of Science, 2018, 1932-6203

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30204 Oncology

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.776

RIV identification code

RIV/00216224:14110/18:00106958

Organization unit

Faculty of Medicine

DOI

http://dx.doi.org/10.1371/journal.pone.0204290

UT WoS

000453451000008

Keywords in English

Acute myeloid leukemia

Abstract

V originále

Acute myeloid leukemia with mutated nucleophosmin (NPMc+AML) forms a distinct AML subgroup with better prognosis which can potentially be associated with immune response against the mutated nucleophosmin (NPM). As the T-cell-mediated immunity involves antigen presentation on HLA class I molecules, we hypothesized that individuals with suitable HLA type could be less prone to develop NPMc+AML. We compared HLA class I distribution in NPMc+AML patient cohort (398 patients from 5 centers) with the HLA allele frequencies of the healthy population and found HLA-A*02, B*07, B*40 and C*07 underrepresented in the NPMc+AML group. Presence of B*07 or C*07:01 antigen was associated with better survival in patients without concomitant FLT3 internal tandem duplication. Candidate NPM-derived immunopeptides were found for B*40 and B*07 using prediction software tools. Our findings suggest that a T-cell-mediated immune response could actually explain better prognosis of NPMc+ patients and provide a rationale for attempts to explore the importance of immunosuppressive mechanisms in this AML subgroup.

Links

NV15-25809A, research and development project

Name: Národní program studia mutací a klonality leukemických buněk u pacientů s akutní myeloidní leukémií

Citovat

KUZELOVA, Katerina, Barbora BRODSKA, Johannes SCHETELIG, Christoph ROLLING, Zdeněk RÁČIL, Juliane Stickel WALZ, Grzegorz HELBIG, Ota FUCHS, Milena VRANA, Pavla PECHERKOVA, Cyril SALEK and Jiří MAYER. Association of HLA class I type with prevalence and outcome of patients with acute myeloid leukemia and mutated nucleophosmin. Plos one. San Francisco: Public Library of Science, 2018, vol. 13, No 12, p. 1-12. ISSN 1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0204290.

@article{1482571,
   author = {Kuzelova, Katerina and Brodska, Barbora and Schetelig, Johannes and Rolling, Christoph and Ráčil, Zdeněk and Walz, Juliane Stickel and Helbig, Grzegorz and Fuchs, Ota and Vrana, Milena and Pecherkova, Pavla and Salek, Cyril and Mayer, Jiří},
   article_location = {San Francisco},
   article_number = {12},
   doi = {http://dx.doi.org/10.1371/journal.pone.0204290},
   keywords = {Acute myeloid leukemia},
   language = {eng},
   issn = {1932-6203},
   journal = {Plos one},
   title = {Association of HLA class I type with prevalence and outcome of patients with acute myeloid leukemia and mutated nucleophosmin},
   volume = {13},
   year = {2018}
}

TY  - JOUR
ID  - 1482571
AU  - Kuzelova, Katerina - Brodska, Barbora - Schetelig, Johannes - Rolling, Christoph - Ráčil, Zdeněk - Walz, Juliane Stickel - Helbig, Grzegorz - Fuchs, Ota - Vrana, Milena - Pecherkova, Pavla - Salek, Cyril - Mayer, Jiří
PY  - 2018
TI  - Association of HLA class I type with prevalence and outcome of patients with acute myeloid leukemia and mutated nucleophosmin
JF  - Plos one
VL  - 13
IS  - 12
SP  - 1-12
EP  - 1-12
PB  - Public Library of Science
SN  - 19326203
KW  - Acute myeloid leukemia
N2  - Acute myeloid leukemia with mutated nucleophosmin (NPMc+AML) forms a distinct AML subgroup with better prognosis which can potentially be associated with immune response against the mutated nucleophosmin (NPM). As the T-cell-mediated immunity involves antigen presentation on HLA class I molecules, we hypothesized that individuals with suitable HLA type could be less prone to develop NPMc+AML. We compared HLA class I distribution in NPMc+AML patient cohort (398 patients from 5 centers) with the HLA allele frequencies of the healthy population and found HLA-A*02, B*07, B*40 and C*07 underrepresented in the NPMc+AML group. Presence of B*07 or C*07:01 antigen was associated with better survival in patients without concomitant FLT3 internal tandem duplication. Candidate NPM-derived immunopeptides were found for B*40 and B*07 using prediction software tools. Our findings suggest that a T-cell-mediated immune response could actually explain better prognosis of NPMc+ patients and provide a rationale for attempts to explore the importance of immunosuppressive mechanisms in this AML subgroup.
ER  -

KUZELOVA, Katerina, Barbora BRODSKA, Johannes SCHETELIG, Christoph ROLLING, Zdeněk RÁČIL, Juliane Stickel WALZ, Grzegorz HELBIG, Ota FUCHS, Milena VRANA, Pavla PECHERKOVA, Cyril SALEK and Jiří MAYER. Association of HLA class I type with prevalence and outcome of patients with acute myeloid leukemia and mutated nucleophosmin. \textit{Plos one}. San Francisco: Public Library of Science, 2018, vol.~13, No~12, p.~1-12. ISSN~1932-6203. Available from: https://dx.doi.org/10.1371/journal.pone.0204290.

Detailed Information on Publication Record