| SEDLAŘÍKOVÁ, Lenka, Božena BOLLOVÁ, Lenka RADOVÁ, Lucie BROŽOVÁ, Jiří JARKOVSKÝ, Martina ALMÁŠI, Miroslav PENKA, Petr KUGLÍK, Viera SANDECKÁ, Martin ŠTORK, Luděk POUR and Sabina ŠEVČÍKOVÁ. Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies. Hematological Oncology. MALDEN, USA: WILEY-BLACKWELL, 2018, vol. 36, No 5, p. 786-791. ISSN 0278-0232. Available from: https://dx.doi.org/10.1002/hon.2554. |
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@article{1482886,
author = {Sedlaříková, Lenka and Bollová, Božena and Radová, Lenka and Brožová, Lucie and Jarkovský, Jiří and Almáši, Martina and Penka, Miroslav and Kuglík, Petr and Sandecká, Viera and Štork, Martin and Pour, Luděk and Ševčíková, Sabina},
article_location = {MALDEN, USA},
article_number = {5},
doi = {http://dx.doi.org/10.1002/hon.2554},
keywords = {biomarker; long noncoding RNA; monoclonal gammopathy of undetermined significance; multiple myeloma; qPCR},
language = {eng},
issn = {0278-0232},
journal = {Hematological Oncology},
title = {Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies},
volume = {36},
year = {2018}
}
TY - JOUR
ID - 1482886
AU - Sedlaříková, Lenka - Bollová, Božena - Radová, Lenka - Brožová, Lucie - Jarkovský, Jiří - Almáši, Martina - Penka, Miroslav - Kuglík, Petr - Sandecká, Viera - Štork, Martin - Pour, Luděk - Ševčíková, Sabina
PY - 2018
TI - Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies
JF - Hematological Oncology
VL - 36
IS - 5
SP - 786-791
EP - 786-791
PB - WILEY-BLACKWELL
SN - 02780232
KW - biomarker
KW - long noncoding RNA
KW - monoclonal gammopathy of undetermined significance
KW - multiple myeloma
KW - qPCR
N2 - Multiple myeloma is the second most common hematological malignancy characterized by focal lesions of malignant plasma cells in the bone marrow. These lesions contain subclones that directly influence survival of patients. Bone marrow biopsies are single-site biopsies and thus cannot contain all information about the tumor. In contrast, liquid biopsies analyze circulating cells and molecules that are secreted from all sites of the tumor. Long noncoding RNA molecules are one class of these molecules. We performed a two-phase biomarker study investigating lncRNA expression profiles in exosomes of peripheral blood serum of newly diagnosed multiple myeloma (MM) patients, monoclonal gammopathy of undetermined significance (MGUS) patients in comparison with healthy donors (HD). Surprisingly, this analysis revealed dysregulation of only one exosomal lncRNA PRINS in MM vs HD. Overall, MM and MGUS patients were distinguished from HD with sensitivity of 84.9% and specificity of 83.3%. Our study suggests a possible diagnostic role for exosomal lncRNA PRINS in monoclonal gammopathies patients.
ER -
SEDLAŘÍKOVÁ, Lenka, Božena BOLLOVÁ, Lenka RADOVÁ, Lucie BROŽOVÁ, Jiří JARKOVSKÝ, Martina ALMÁŠI, Miroslav PENKA, Petr KUGLÍK, Viera SANDECKÁ, Martin ŠTORK, Luděk POUR and Sabina ŠEVČÍKOVÁ. Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies. \textit{Hematological Oncology}. MALDEN, USA: WILEY-BLACKWELL, 2018, vol.~36, No~5, p.~786-791. ISSN~0278-0232. Available from: https://dx.doi.org/10.1002/hon.2554.
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