Human White Adipose Tissue Metabolome: Current Perspective

J 2018

Human White Adipose Tissue Metabolome: Current Perspective

KUČERA, Jan, Zdeněk SPÁČIL, David FRIEDECKÝ, Jan NOVÁK, Matej PEKAŘ et. al.

Basic information

Original name

Human White Adipose Tissue Metabolome: Current Perspective

Authors

KUČERA, Jan (203 Czech Republic, belonging to the institution), Zdeněk SPÁČIL (203 Czech Republic, belonging to the institution), David FRIEDECKÝ (203 Czech Republic), Jan NOVÁK (203 Czech Republic, belonging to the institution), Matej PEKAŘ (703 Slovakia, belonging to the institution) and Julie BIENERTOVÁ VAŠKŮ (203 Czech Republic, guarantor, belonging to the institution)

Edition

OBESITY, HOBOKEN, WILEY, 2018, 1930-7381

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30308 Nutrition, Dietetics

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

Impact factor

Impact factor: 3.969

RIV identification code

RIV/00216224:14310/18:00105235

Organization unit

Faculty of Science

DOI

http://dx.doi.org/10.1002/oby.22336

UT WoS

000450678700011

Keywords in English

OBESITY; ACID; ASSOCIATION; LIPIDOMICS; DISCOVERY; PROFILES; HEALTHY

Abstract

V originále

Objective Interest in metabolites produced by adipose tissue has increased substantially in the past several decades. Previously regarded as an inert energy storage depot, adipose tissue is now viewed as a complex metabolically active organ with considerable impact on human health. The emerging field of mass spectrometry-based metabolomics presents a powerful tool for the study of processes in complex biological matrices including adipose tissue. Results A large number of structurally distinct metabolites can be analyzed to facilitate the investigation of differences between physiological and pathophysiological metabolic profiles associated with adipose tissue. Understanding the molecular basis of adipose tissue regulation can thereby provide insight into the monitoring of obesity-related metabolic disorders and lead to the development of novel diagnostic and prognostic biomarkers. Conclusions This review provides the current state of knowledge, recent progress, and critical evaluation of metabolomics approaches in the context of white adipose tissue and obesity. An overview of basic principles and resources describing individual groups of metabolites analyzed in white adipose tissue and biological fluids is given. The focus is on metabolites that can serve as reliable biomarkers indicative of metabolic alterations associated with obesity.

Links

CZ.02.1.01/0.0/0.0/16_013/0001761, interní kód MU

Name: RECETOX RI - OP VVV (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR, Priority axis 1: Strengthening capacities for high-quality research

EF15_003/0000469, research and development project

Name: Cetocoen Plus

LM2015051, research and development project

Name: Centrum pro výzkum toxických látek v prostředí (Acronym: RECETOX RI)

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

KUČERA, Jan, Zdeněk SPÁČIL, David FRIEDECKÝ, Jan NOVÁK, Matej PEKAŘ and Julie BIENERTOVÁ VAŠKŮ. Human White Adipose Tissue Metabolome: Current Perspective. OBESITY. HOBOKEN: WILEY, 2018, vol. 26, No 12, p. 1870-1878. ISSN 1930-7381. Available from: https://dx.doi.org/10.1002/oby.22336.

@article{1483136,
   author = {Kučera, Jan and Spáčil, Zdeněk and Friedecký, David and Novák, Jan and Pekař, Matej and Bienertová Vašků, Julie},
   article_location = {HOBOKEN},
   article_number = {12},
   doi = {http://dx.doi.org/10.1002/oby.22336},
   keywords = {OBESITY; ACID; ASSOCIATION; LIPIDOMICS; DISCOVERY; PROFILES; HEALTHY},
   language = {eng},
   issn = {1930-7381},
   journal = {OBESITY},
   title = {Human White Adipose Tissue Metabolome: Current Perspective},
   url = {https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22336},
   volume = {26},
   year = {2018}
}

TY  - JOUR
ID  - 1483136
AU  - Kučera, Jan - Spáčil, Zdeněk - Friedecký, David - Novák, Jan - Pekař, Matej - Bienertová Vašků, Julie
PY  - 2018
TI  - Human White Adipose Tissue Metabolome: Current Perspective
JF  - OBESITY
VL  - 26
IS  - 12
SP  - 1870-1878
EP  - 1870-1878
PB  - WILEY
SN  - 19307381
KW  - OBESITY
KW  - ACID
KW  - ASSOCIATION
KW  - LIPIDOMICS
KW  - DISCOVERY
KW  - PROFILES
KW  - HEALTHY
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22336
L2  - https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22336
N2  - Objective Interest in metabolites produced by adipose tissue has increased substantially in the past several decades. Previously regarded as an inert energy storage depot, adipose tissue is now viewed as a complex metabolically active organ with considerable impact on human health. The emerging field of mass spectrometry-based metabolomics presents a powerful tool for the study of processes in complex biological matrices including adipose tissue. Results A large number of structurally distinct metabolites can be analyzed to facilitate the investigation of differences between physiological and pathophysiological metabolic profiles associated with adipose tissue. Understanding the molecular basis of adipose tissue regulation can thereby provide insight into the monitoring of obesity-related metabolic disorders and lead to the development of novel diagnostic and prognostic biomarkers. Conclusions This review provides the current state of knowledge, recent progress, and critical evaluation of metabolomics approaches in the context of white adipose tissue and obesity. An overview of basic principles and resources describing individual groups of metabolites analyzed in white adipose tissue and biological fluids is given. The focus is on metabolites that can serve as reliable biomarkers indicative of metabolic alterations associated with obesity.
ER  -

KUČERA, Jan, Zdeněk SPÁČIL, David FRIEDECKÝ, Jan NOVÁK, Matej PEKAŘ and Julie BIENERTOVÁ VAŠKŮ. Human White Adipose Tissue Metabolome: Current Perspective. \textit{OBESITY}. HOBOKEN: WILEY, 2018, vol.~26, No~12, p.~1870-1878. ISSN~1930-7381. Available from: https://dx.doi.org/10.1002/oby.22336.

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