| KUČERA, Jan, Zdeněk SPÁČIL, David FRIEDECKÝ, Jan NOVÁK, Matej PEKAŘ and Julie BIENERTOVÁ VAŠKŮ. Human White Adipose Tissue Metabolome: Current Perspective. OBESITY. HOBOKEN: WILEY, 2018, vol. 26, No 12, p. 1870-1878. ISSN 1930-7381. Available from: https://dx.doi.org/10.1002/oby.22336. |
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@article{1483136,
author = {Kučera, Jan and Spáčil, Zdeněk and Friedecký, David and Novák, Jan and Pekař, Matej and Bienertová Vašků, Julie},
article_location = {HOBOKEN},
article_number = {12},
doi = {http://dx.doi.org/10.1002/oby.22336},
keywords = {OBESITY; ACID; ASSOCIATION; LIPIDOMICS; DISCOVERY; PROFILES; HEALTHY},
language = {eng},
issn = {1930-7381},
journal = {OBESITY},
title = {Human White Adipose Tissue Metabolome: Current Perspective},
url = {https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22336},
volume = {26},
year = {2018}
}
TY - JOUR
ID - 1483136
AU - Kučera, Jan - Spáčil, Zdeněk - Friedecký, David - Novák, Jan - Pekař, Matej - Bienertová Vašků, Julie
PY - 2018
TI - Human White Adipose Tissue Metabolome: Current Perspective
JF - OBESITY
VL - 26
IS - 12
SP - 1870-1878
EP - 1870-1878
PB - WILEY
SN - 19307381
KW - OBESITY
KW - ACID
KW - ASSOCIATION
KW - LIPIDOMICS
KW - DISCOVERY
KW - PROFILES
KW - HEALTHY
UR - https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22336
L2 - https://onlinelibrary.wiley.com/doi/full/10.1002/oby.22336
N2 - Objective Interest in metabolites produced by adipose tissue has increased substantially in the past several decades. Previously regarded as an inert energy storage depot, adipose tissue is now viewed as a complex metabolically active organ with considerable impact on human health. The emerging field of mass spectrometry-based metabolomics presents a powerful tool for the study of processes in complex biological matrices including adipose tissue. Results A large number of structurally distinct metabolites can be analyzed to facilitate the investigation of differences between physiological and pathophysiological metabolic profiles associated with adipose tissue. Understanding the molecular basis of adipose tissue regulation can thereby provide insight into the monitoring of obesity-related metabolic disorders and lead to the development of novel diagnostic and prognostic biomarkers. Conclusions This review provides the current state of knowledge, recent progress, and critical evaluation of metabolomics approaches in the context of white adipose tissue and obesity. An overview of basic principles and resources describing individual groups of metabolites analyzed in white adipose tissue and biological fluids is given. The focus is on metabolites that can serve as reliable biomarkers indicative of metabolic alterations associated with obesity.
ER -
KUČERA, Jan, Zdeněk SPÁČIL, David FRIEDECKÝ, Jan NOVÁK, Matej PEKAŘ and Julie BIENERTOVÁ VAŠKŮ. Human White Adipose Tissue Metabolome: Current Perspective. \textit{OBESITY}. HOBOKEN: WILEY, 2018, vol.~26, No~12, p.~1870-1878. ISSN~1930-7381. Available from: https://dx.doi.org/10.1002/oby.22336.
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