| LEE, Y., N.H. KIM, E.S. CHO, J.H. YANG, Y.H. CHA, H.E. KANG, J.S. YUN, S.B. CHO, S.H. LEE, Petra PACLÍKOVÁ, Tomasz Witold RADASZKIEWICZ, Vítězslav BRYJA, C.G. KANG, Y.S. YUK, S.Y. CHA, S.Y. KIM, H.S. KIM and J.I. YOOK. Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner. Nature Communications. London: Nature Publishing Group, 2018, vol. 9, No 1, p. 1-16. ISSN 2041-1723. Available from: https://dx.doi.org/10.1038/s41467-018-04757-w. |
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@article{1483380,
author = {Lee, Y. and Kim, N.H. and Cho, E.S. and Yang, J.H. and Cha, Y.H. and Kang, H.E. and Yun, J.S. and Cho, S.B. and Lee, S.H. and Paclíková, Petra and Radaszkiewicz, Tomasz Witold and Bryja, Vítězslav and Kang, C.G. and Yuk, Y.S. and Cha, S.Y. and Kim, S.Y. and Kim, H.S. and Yook, J.I.},
article_location = {London},
article_number = {1},
doi = {http://dx.doi.org/10.1038/s41467-018-04757-w},
keywords = {ACTIVATED PROTEIN-KINASE; PLANAR CELL POLARITY; ORGAN SIZE CONTROL; HIPPO PATHWAY; BETA-CATENIN; ENERGY STRESS; CONTACT INHIBITION; SIGNALING-PATHWAY; CANCER; LKB1},
language = {eng},
issn = {2041-1723},
journal = {Nature Communications},
title = {Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner},
url = {https://www.nature.com/articles/s41467-018-04757-w},
volume = {9},
year = {2018}
}
TY - JOUR
ID - 1483380
AU - Lee, Y. - Kim, N.H. - Cho, E.S. - Yang, J.H. - Cha, Y.H. - Kang, H.E. - Yun, J.S. - Cho, S.B. - Lee, S.H. - Paclíková, Petra - Radaszkiewicz, Tomasz Witold - Bryja, Vítězslav - Kang, C.G. - Yuk, Y.S. - Cha, S.Y. - Kim, S.Y. - Kim, H.S. - Yook, J.I.
PY - 2018
TI - Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner
JF - Nature Communications
VL - 9
IS - 1
SP - 1-16
EP - 1-16
PB - Nature Publishing Group
SN - 20411723
KW - ACTIVATED PROTEIN-KINASE
KW - PLANAR CELL POLARITY
KW - ORGAN SIZE CONTROL
KW - HIPPO PATHWAY
KW - BETA-CATENIN
KW - ENERGY STRESS
KW - CONTACT INHIBITION
KW - SIGNALING-PATHWAY
KW - CANCER
KW - LKB1
UR - https://www.nature.com/articles/s41467-018-04757-w
N2 - Phosphorylation-dependent YAP translocation is a well-known intracellular mechanism of the Hippo pathway; however, the molecular effectors governing YAP cytoplasmic translocation remains undefined. Recent findings indicate that oncogenic YAP paradoxically suppresses Wnt activity. Here, we show that Wnt scaffolding protein Dishevelled (DVL) is responsible for cytosolic translocation of phosphorylated YAP. Mutational inactivation of the nuclear export signal embedded in DVL leads to nuclear YAP retention, with an increase in TEAD transcriptional activity. DVL is also required for YAP subcellular localization induced by E-cadherin, a-catenin, or AMPK activation. Importantly, the nuclear-cytoplasmic trafficking is dependent on the p53-Lats2 or LKB1-AMPK tumor suppressor axes, which determine YAP phosphorylation status. In vivo and clinical data support that the loss of p53 or LKB1 relieves DVL-linked reciprocal inhibition between the Wnt and nuclear YAP activity. Our observations provide mechanistic insights into controlled proliferation coupled with epithelial polarity during development and human cancer.
ER -
LEE, Y., N.H. KIM, E.S. CHO, J.H. YANG, Y.H. CHA, H.E. KANG, J.S. YUN, S.B. CHO, S.H. LEE, Petra PACLÍKOVÁ, Tomasz Witold RADASZKIEWICZ, Vítězslav BRYJA, C.G. KANG, Y.S. YUK, S.Y. CHA, S.Y. KIM, H.S. KIM and J.I. YOOK. Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner. \textit{Nature Communications}. London: Nature Publishing Group, 2018, vol.~9, No~1, p.~1-16. ISSN~2041-1723. Available from: https://dx.doi.org/10.1038/s41467-018-04757-w.
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