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@article{1483381,
author = {Mentink, R.A. and Rella, L. and Radaszkiewicz, Tomasz Witold and Gybeľ, Tomáš and Betist, M.C. and Bryja, Vítězslav and Korswagen, H.C.},
article_location = {San Francisco},
article_number = {12},
doi = {http://dx.doi.org/10.1371/journal.pgen.1007840},
keywords = {CANONICAL WNT PATHWAY; C. ELEGANS; NEUROBLAST MIGRATION; GENE-EXPRESSION; VANGL2; GASTRULATION; MUTATIONS; DIVISION; AXIS; PHOSPHORYLATION},
language = {eng},
issn = {1553-7404},
journal = {PLoS Genetics},
title = {The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/beta-catenin signaling through a Dvl dependent mechanism},
url = {https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007840},
volume = {14},
year = {2018}
}
TY - JOUR
ID - 1483381
AU - Mentink, R.A. - Rella, L. - Radaszkiewicz, Tomasz Witold - Gybeľ, Tomáš - Betist, M.C. - Bryja, Vítězslav - Korswagen, H.C.
PY - 2018
TI - The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/beta-catenin signaling through a Dvl dependent mechanism
JF - PLoS Genetics
VL - 14
IS - 12
SP - 1-22
EP - 1-22
PB - Public Library of Science
SN - 15537404
KW - CANONICAL WNT PATHWAY
KW - C. ELEGANS
KW - NEUROBLAST MIGRATION
KW - GENE-EXPRESSION
KW - VANGL2
KW - GASTRULATION
KW - MUTATIONS
KW - DIVISION
KW - AXIS
KW - PHOSPHORYLATION
UR - https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007840
L2 - https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007840
N2 - Van Gogh-like (Vangl) and Prickle (Pk) are core components of the non-canonical Wnt planar cell polarity pathway that controls epithelial polarity and cell migration. Studies in vertebrate model systems have suggested that Vangl and Pk may also inhibit signaling through the canonical Wnt/beta-catenin pathway, but the functional significance of this potential crosstalk is unclear. In the nematode C. elegans, the Q neuroblasts and their descendants migrate in opposite directions along the anteroposterior body axis. The direction of these migrations is specified by Wnt signaling, with activation of canonical Wnt signaling driving posterior migration, and non-canonical Wnt signaling anterior migration. Here, we show that the Vangl ortholog VANG-1 influences the Wnt signaling response of the Q neuroblasts by negatively regulating canonical Wnt signaling. This inhibitory activity depends on a carboxyterminal PDZ binding motif in VANG-1 and the Dishevelled ortholog MIG-5, but is independent of the Pk ortholog PRKL-1. Moreover, using Vangl1 and Vangl2 double mutant cells, we show that a similar mechanism acts in mammalian cells. We conclude that cross-talk between VANG-1/Vangl and the canonical Wnt pathway is an evolutionarily conserved mechanism that ensures robust specification of Wnt signaling responses.
ER -
MENTINK, R.A., L. RELLA, Tomasz Witold RADASZKIEWICZ, Tomáš GYBEĽ, M.C. BETIST, Vítězslav BRYJA and H.C. KORSWAGEN. The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/beta-catenin signaling through a Dvl dependent mechanism. \textit{PLoS Genetics}. San Francisco: Public Library of Science, 2018, vol.~14, No~12, p.~1-22. ISSN~1553-7404. Available from: https://dx.doi.org/10.1371/journal.pgen.1007840.
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