DAMBORSKÝ, Jiří, Fedor NIKULENKOV, Alexandra SISÁKOVÁ, Štěpán HAVEL, Lumír KREJČÍ, Benoit Jean-Pierre CARBAIN, Jan BREZOVSKÝ, Lukáš DANIEL and Kamil PARUCH. Pyrazolotriazines as inhibitors of nucleases. 2018.
Other formats:   BibTeX LaTeX RIS
Basic information
Original name Pyrazolotriazines as inhibitors of nucleases
Authors DAMBORSKÝ, Jiří (203 Czech Republic, belonging to the institution), Fedor NIKULENKOV (203 Czech Republic, belonging to the institution), Alexandra SISÁKOVÁ (703 Slovakia, belonging to the institution), Štěpán HAVEL (203 Czech Republic, belonging to the institution), Lumír KREJČÍ (203 Czech Republic, belonging to the institution), Benoit Jean-Pierre CARBAIN (250 France, belonging to the institution), Jan BREZOVSKÝ (203 Czech Republic, belonging to the institution), Lukáš DANIEL (203 Czech Republic, belonging to the institution) and Kamil PARUCH (203 Czech Republic, belonging to the institution).
Edition Number: US 9969741 B2, Publisher: USPTO, Place of publication: USA, Owner's name: Masarykova univerzita, 2018.
Other information
Original language English
Type of outcome Patent
Field of Study 10400 1.4 Chemical sciences
Country of publisher United States of America
Confidentiality degree is not subject to a state or trade secret
WWW URL
RIV identification code RIV/00216224:14310/18:00105284
Organization unit Faculty of Science
Keywords in English inhibitor; nuclease; DNA repair; pyrazolotriazine; MUS81
Tags podil
Changed by Changed by: doc. Mgr. Kamil Paruch, Ph.D., učo 108413. Changed: 13/4/2019 15:10.
Abstract
The present invention relates to substituted heterocycles as inhibitors of nudeases MUS81 and MRE11, pharmaceutical compositions containing the compounds, and pharmaceutical use of the compounds and compositions in the treatment of the diseases such as, for example, cancer.
Links
LM2015063, research and development projectName: Národní infrastruktura chemické biologie (Acronym: CZ-­OPENSCREEN)
Investor: Ministry of Education, Youth and Sports of the CR
MUNI/M/1894/2014, interní kód MUName: Development of new MUS81 nuclease inhibitors as chemical biology probe with clinical progression
Investor: Masaryk University, INTERDISCIPLINARY - Interdisciplinary research projects
PrintDisplayed: 17/8/2024 12:32